Cirrhosis-associated immune dysfunction

A Albillos, R Martin-Mateos, S Van der Merwe… - Nature Reviews …, 2022 - nature.com
The term cirrhosis-associated immune dysfunction (CAID) comprises the distinctive
spectrum of immune alterations associated with the course of end-stage liver disease …

Metabolism of tissue macrophages in homeostasis and pathology

SK Wculek, G Dunphy, I Heras-Murillo… - Cellular & molecular …, 2022 - nature.com
Cellular metabolism orchestrates the intricate use of tissue fuels for catabolism and
anabolism to generate cellular energy and structural components. The emerging field of …

Oxidative phosphorylation selectively orchestrates tissue macrophage homeostasis

SK Wculek, I Heras-Murillo, A Mastrangelo, D Mañanes… - Immunity, 2023 - cell.com
In vitro studies have associated oxidative phosphorylation (OXPHOS) with anti-inflammatory
macrophages, whereas pro-inflammatory macrophages rely on glycolysis. However, the …

Glutamine: metabolism and immune function, supplementation and clinical translation

V Cruzat, M Macedo Rogero, K Noel Keane, R Curi… - Nutrients, 2018 - mdpi.com
Glutamine is the most abundant and versatile amino acid in the body. In health and disease,
the rate of glutamine consumption by immune cells is similar or greater than glucose. For …

Nitric oxide orchestrates metabolic rewiring in M1 macrophages by targeting aconitase 2 and pyruvate dehydrogenase

EM Palmieri, M Gonzalez-Cotto, WA Baseler… - Nature …, 2020 - nature.com
Profound metabolic changes are characteristic of macrophages during classical activation
and have been implicated in this phenotype. Here we demonstrate that nitric oxide (NO) …

[HTML][HTML] Lactate is a natural suppressor of RLR signaling by targeting MAVS

W Zhang, G Wang, ZG Xu, H Tu, F Hu, J Dai, Y Chang… - Cell, 2019 - cell.com
Summary RLR-mediated type I IFN production plays a pivotal role in elevating host immunity
for viral clearance and cancer immune surveillance. Here, we report that glycolysis, which is …

[HTML][HTML] Tumour necrosis factor signalling in health and disease

J Holbrook, S Lara-Reyna, H Jarosz-Griffiths… - …, 2019 - ncbi.nlm.nih.gov
The master pro-inflammatory cytokine, tumour necrosis factor (TNF), has been shown to
modulate multiple signalling pathways, with wide-ranging downstream effects. TNF plays a …

Tumour-elicited neutrophils engage mitochondrial metabolism to circumvent nutrient limitations and maintain immune suppression

CM Rice, LC Davies, JJ Subleski, N Maio… - Nature …, 2018 - nature.com
Neutrophils are a vital component of immune protection, yet in cancer they may promote
tumour progression, partly by generating reactive oxygen species (ROS) that disrupts …

More than just protein building blocks: how amino acids and related metabolic pathways fuel macrophage polarization

M Kieler, M Hofmann, G Schabbauer - The FEBS journal, 2021 - Wiley Online Library
Macrophages represent the first line of defence in innate immune responses and
additionally serve important functions for the regulation of host inflammation and tissue …

[PDF][PDF] Cardiac macrophages and emerging roles for their metabolism after myocardial infarction

EB Thorp - Journal of Clinical Investigation, 2023 - Am Soc Clin Investig
Interest in cardioimmunology has reached new heights as the experimental cardiology field
works to tap the unrealized potential of immunotherapy for clinical care. Within this space is …