The pathogenesis of psoriatic arthritis

DJ Veale, U Fearon - The Lancet, 2018 - thelancet.com
Psoriatic arthritis is a chronic, immune-mediated, inflammatory arthropathy that presents with
inflammation of the joints and entheses, including those of the axial skeleton, and is …

Hypoxia, oxidative stress and inflammation

T McGarry, M Biniecka, DJ Veale, U Fearon - Free Radical Biology and …, 2018 - Elsevier
Inflammatory Arthritis is characterized by synovial proliferation, neovascularization and
leukocyte extravasation leading to joint destruction and functional disability. Efficiency of …

[HTML][HTML] The complement system drives local inflammatory tissue priming by metabolic reprogramming of synovial fibroblasts

J Friščić, M Böttcher, C Reinwald, H Bruns, B Wirth… - Immunity, 2021 - cell.com
Arthritis typically involves recurrence and progressive worsening at specific predilection
sites, but the checkpoints between remission and persistence remain unknown. Here, we …

Resolution of chronic inflammatory disease: universal and tissue-specific concepts

G Schett, MF Neurath - Nature communications, 2018 - nature.com
Inflammation and its resolution is under-studied in medicine despite being essential for
understanding the development of chronic inflammatory disease. In this review article, we …

[PDF][PDF] One year in review 2018: pathogenesis of rheumatoid arthritis

E Calabresi, F Petrelli, AF Bonifacio… - Clin Exp …, 2018 - clinexprheumatol.org
Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease that primarily
affects joints. The several mechanisms involved in the development of the disease are not …

Cellular metabolic adaptations in rheumatoid arthritis and their therapeutic implications

U Fearon, MM Hanlon, A Floudas… - Nature Reviews …, 2022 - nature.com
Activation of endothelium and immune cells is fundamental to the initiation of autoimmune
diseases such as rheumatoid arthritis (RA), and it results in trans-endothelial cell migration …

Glycolysis rate-limiting enzymes: novel potential regulators of rheumatoid arthritis pathogenesis

J Zuo, J Tang, M Lu, Z Zhou, Y Li, H Tian, E Liu… - Frontiers in …, 2021 - frontiersin.org
Rheumatoid arthritis (RA) is a classic autoimmune disease characterized by uncontrolled
synovial proliferation, pannus formation, cartilage injury, and bone destruction. The specific …

Mitochondrial dysfunction and oxidative stress in rheumatoid arthritis

MJ López-Armada, JA Fernández-Rodríguez… - Antioxidants, 2022 - mdpi.com
Control of excessive mitochondrial oxidative stress could provide new targets for both
preventive and therapeutic interventions in the treatment of chronic inflammation or any …

[HTML][HTML] Understanding glycosylation: Regulation through the metabolic flux of precursor pathways

AF Scheper, J Schofield, R Bohara, T Ritter… - Biotechnology …, 2023 - Elsevier
Glycosylation is how proteins and lipids are modified with complex carbohydrates known as
glycans. The post-translational modification of proteins with glycans is not a template-driven …

The relevance of pathophysiological alterations in redox signaling of 4-hydroxynonenal for pharmacological therapies of major stress-associated diseases

M Jaganjac, L Milkovic, A Gegotek, M Cindric… - Free Radical Biology …, 2020 - Elsevier
Modern analytical methods combined with the modern concepts of redox signaling revealed
4-hydroxy-2-nonenal (4-HNE) as particular growth regulating factor involved in redox …