Role of keratinocytes in sensitive skin

M Talagas, L Misery - Frontiers in medicine, 2019 - frontiersin.org
Sensitive skin is a clinical syndrome defined by the occurrence of unpleasant sensations
such as burning, stinging, tingling, pricking, or itching in response to various normally …

Neurological disturbances of ciguatera poisoning: clinical features and pathophysiological basis

K L'Herondelle, M Talagas, O Mignen, L Misery… - Cells, 2020 - mdpi.com
Ciguatera fish poisoning (CFP), the most prevalent seafood poisoning worldwide, is caused
by the consumption of tropical and subtropical fish contaminated with potent neurotoxins …

Keratinocytes communicate with sensory neurons via synaptic‐like contacts

M Talagas, N Lebonvallet, R Leschiera… - Annals of …, 2020 - Wiley Online Library
Objective Pain, temperature, and itch are conventionally thought to be exclusively
transduced by the intraepidermal nerve endings. Although recent studies have shown that …

Immune effects of the neurotoxins ciguatoxins and brevetoxins

O Pierre, L Misery, M Talagas, R Le Garrec - Toxicon, 2018 - Elsevier
Abstract Ciguatoxins (CTXs) and brevetoxins (PbTxs) are phycotoxins that can accumulate
along the marine food chain and thus cause seafood poisoning in humans, namely …

Ciguatoxins Evoke Potent CGRP Release by Activation of Voltage-Gated Sodium Channel Subtypes NaV1.9, NaV1.7 and NaV1.1

F Touska, S Sattler, P Malsch, RJ Lewis, PW Reeh… - Marine Drugs, 2017 - mdpi.com
Ciguatoxins (CTXs) are marine toxins that cause ciguatera fish poisoning, a debilitating
disease dominated by sensory and neurological disturbances that include cold allodynia …

Sensitive skins may be neuropathic disorders: lessons from studies on skin and other organs

L Misery - Cosmetics, 2021 - mdpi.com
Sensitive skin can be considered a neuropathic disorder. Sensory disorders and the
decrease in intra-epidermal nerve ending density are strong arguments for small-fiber …

PAR2, keratinocytes, and cathepsin S mediate the sensory effects of ciguatoxins responsible for ciguatera poisoning

K L'herondelle, O Pierre, S Fouyet, R Leschiera… - Journal of Investigative …, 2021 - Elsevier
Ciguatera fish poisoning is caused by the consumption of fish contaminated with ciguatoxins
(CTXs). The most distressing symptoms are cutaneous sensory disturbances, including cold …

New human in vitro co‐culture model of keratinocytes and sensory neurons like cells releasing substance P with an evaluation of the expression of ZIKV entry …

C Bocciarelli, N Cordel, R Leschiera… - Experimental …, 2023 - Wiley Online Library
During the course of acute ZIKV infection, pruritus is a cardinal symptom widely documented
in the literature. Its frequent association with dysesthesia and several dysautonomic …

A new tool to test active ingredient using lactic acid in vitro, a help to understand cellular mechanism involved in stinging test: An example using a bacterial …

M Sakka, R Leschiera, C Le Gall‐Ianotto… - Experimental …, 2018 - Wiley Online Library
The stinging test is an in vivo protocol that evaluates sensitive skin using lactic acid (LA). A
soothing sensation of cosmetics or ingredients can be also appreciated through a decrease …

Pacific-ciguatoxin-2 and brevetoxin-1 induce the sensitization of sensory receptors mediating pain and pruritus in sensory neurons

O Pierre, M Fouchard, N Le Goux, P Buscaglia… - Marine Drugs, 2021 - mdpi.com
Ciguatera fish poisoning (CFP) and neurotoxic shellfish poisoning syndromes are induced
by the consumption of seafood contaminated by ciguatoxins and brevetoxins. Both toxins …