Targeting PI3K in cancer: mechanisms and advances in clinical trials

J Yang, J Nie, X Ma, Y Wei, Y Peng, X Wei - Molecular cancer, 2019 - Springer
Abstract Phosphatidylinositol-3-kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR)
signaling is one of the most important intracellular pathways, which can be considered as a …

PI3K/AKT/mTOR signaling in gastric cancer: Epigenetics and beyond

S Fattahi, F Amjadi-Moheb, R Tabaripour, GH Ashrafi… - Life Sciences, 2020 - Elsevier
Abstract PI3K/AKT/mTOR pathway is one of the most important signaling pathways involved
in normal cellular processes. Its aberrant activation modulates autophagy, epithelial …

Long non-coding RNAs regulate drug resistance in cancer

K Liu, L Gao, X Ma, JJ Huang, J Chen, L Zeng… - Molecular cancer, 2020 - Springer
Chemoresistance, whether intrinsic or acquired, is a major obstacle in the treatment of
cancer. The resistance of cancer cells to chemotherapeutic drugs can result from various …

LncRNAs as potential diagnostic and prognostic biomarkers in gastric cancer: a novel approach to personalized medicine

S Fattahi, M Kosari‐Monfared… - Journal of cellular …, 2020 - Wiley Online Library
Gastric cancer is the third leading cause of cancer death with 5‐year survival rate of about
30–35%. Since early detection is associated with decreased mortality, identification of novel …

Alteration of epigenetic regulation by long noncoding RNAs in cancer

M Morlando, A Fatica - International journal of molecular sciences, 2018 - mdpi.com
Long noncoding RNAs (lncRNAs) are important regulators of the epigenetic status of the
human genome. Besides their participation to normal physiology, lncRNA expression and …

[PDF][PDF] Tumor suppressor and oncogenic role of long non-coding RNAs in cancer.

E Guzel, TM Okyay, B Yalcinkaya… - Northern clinics of …, 2020 - jag.journalagent.com
Non-coding RNAs are RNA molecules that are not translated into the protein, making up the
vast majority of the human genome. Long non-coding RNAs (lncRNA) are in the RNA group …

LncRNA UCA1 promotes SOX12 expression in breast cancer by regulating m6A modification of miR-375 by METTL14 through DNA methylation

C Zhao, X Ling, Y Xia, B Yan, Q Guan - Cancer gene therapy, 2022 - nature.com
Breast cancer, a multifactorial disease, represents one of the leading causes of cancer-
related morbidity and mortality in women. This study set out to elucidate the underlying …

[HTML][HTML] UCA1 long non-coding RNA: An update on its roles in malignant behavior of cancers

S Ghafouri-Fard, M Taheri - Biomedicine & Pharmacotherapy, 2019 - Elsevier
The lncRNA urothelial carcinoma-associated 1 (UCA1) is a 1.4 kb long transcript which has
been firstly recognized in human bladder cancer cell line. Subsequent studies revealed its …

The emerging role of major regulatory RNAs in cancer control

X Dai, AC Kaushik, J Zhang - Frontiers in oncology, 2019 - frontiersin.org
Alterations and personal variations of RNA interactions have been mechanistically coupled
with disease etiology and phenotypical variations. RNA biomarkers, RNA mimics, and RNA …

[PDF][PDF] RETRACTED: Long Noncoding RNA UCA1 Regulates PRL-3 Expression by Sponging MicroRNA-495 to Promote the Progression of Gastric Cancer

Y Cao, JB Xiong, GY Zhang, Y Liu, ZG Jie… - Molecular Therapy-Nucleic …, 2020 - cell.com
Gastric cancer (GC) is among the most frequently occurring malignancies worldwide. In
recent years, long noncoding RNAs (lncRNAs) have been widely studied because of their …