Obesity is a complex disease that affects whole body metabolism and is associated with an
increased risk of cardiovascular disease (CVD) and Type 2 diabetes (T2D). Physical …

AMP-activated protein kinase (AMPK) is a metabolic sensor in mammals that is activated
when ATP levels in the cell decrease. AMPK is a heterotrimeric protein that comprises 3 …

Skeletal muscle plays an important role in regulating whole-body energy expenditure given
it is a major site for glucose and lipid oxidation. Obesity and type 2 diabetes are causally …

Obesity develops when energy intake exceeds energy expenditure. Although most current
obesity therapies are focused on reducing calorific intake, recent data suggest that …

Lipid metabolism is tightly controlled by the nutritional state of the organism. Nutrient-rich
conditions increase lipogenesis, whereas nutrient deprivation promotes fat oxidation. In this …

Weight loss remains the most common therapy advocated for reducing hepatic lipid in
obesity and nonalcoholic fatty liver disease. Yet, reduction of body weight by lifestyle …

Metformin is a widely used antidiabetic agent, which regulates glucose homeostasis through
inhibition of liver glucose production and an increase in muscle glucose uptake. Recent …

Calorie-enriched diet and lack of exercise are causing a worldwide surge of obesity, insulin
resistance and lipid accretion in liver (ie hepatic steatosis), which can lead to steatohepatitis …

Angiogenesis is necessary for the growth of adipose tissue. Dietary polyphenols may
suppress growth of adipose tissue through their antiangiogenic activity and by modulating …

The prevalence of overweight and obesity and their associated metabolic disorders are
considered a major threat to the public's health. While several diet and exercise programs …