Cancer stem cells (CSCs), also known as tumor‐initiating cells (TICs), are suggested to be
responsible for drug resistance and cancer relapse due in part to their ability to self‐renew …

Temozolomide (TMZ) is a first-choice alkylating agent inducted as a gold standard therapy
for glioblastoma multiforme (GBM) and astrocytoma. A majority of patients do not respond to …

Glioblastoma (GBM) is the highest-grade form of glioma, as well as one of the most
aggressive types of cancer, exhibiting rapid cellular growth and highly invasive behavior …

The Notch signaling pathway plays an essential role in a wide variety of biological
processes including cell fate determination of vascular endothelial cells and the regulation …

The term “cancer stem cell”(CSC) refers to a cancer cell with the following features:
clonogenic ability, the expression of stem cell markers, differentiation into cells of different …

Drug resistance is the main culprit of failure in cancer therapy that may lead to cancer
relapse. This resistance mostly originates from rare, but impactful presence of cancer stem …

Despite advances in neurosurgical techniques and radio-/chemotherapy, the treatment of
brain tumors remains a challenge. This is particularly true for the most frequent and fatal …

Chemotherapy is one of the standard methods of treatment in many cancers. While
chemotherapy is often capable of inducing cell death in tumors and reducing the tumor bulk …

Similar to normal tissue, many tumors have a hierarchical organization where tumorigenic
cancer stem cells (CSCs) differentiate into non-tumorigenic progenies. A host of studies …

Glioblastoma (GBM) is a highly fatal and recurrent brain cancer without a complete
prevailing remedy. Although the synthetic nanotechnology-based approaches exhibit …