Integration of substrate-and flow-derived stresses in endothelial cell mechanobiology
CA Dessalles, C Leclech, A Castagnino… - Communications …, 2021 - nature.com
Endothelial cells (ECs) lining all blood vessels are subjected to large mechanical stresses
that regulate their structure and function in health and disease. Here, we review EC …
that regulate their structure and function in health and disease. Here, we review EC …
Microfluidic platforms for mechanobiology
Mechanotransduction has been a topic of considerable interest since early studies
demonstrated a link between mechanical force and biological response. Until recently …
demonstrated a link between mechanical force and biological response. Until recently …
Mimicking arterial thrombosis in a 3D-printed microfluidic in vitro vascular model based on computed tomography angiography data
Arterial thrombosis is the main instigating factor of heart attacks and strokes, which result in
over 14 million deaths worldwide every year. The mechanism of thrombosis involves factors …
over 14 million deaths worldwide every year. The mechanism of thrombosis involves factors …
Vasculature-on-a-chip for in vitro disease models
Vascularization, the formation of new blood vessels, is an essential biological process. As
the vasculature is involved in various fundamental physiological phenomena and closely …
the vasculature is involved in various fundamental physiological phenomena and closely …
A microfluidic system for studying the effects of disturbed flow on endothelial cells
Arterial endothelium experience physical stress associated with blood flow and play a
central role in maintaining vascular integrity and homeostasis in response to hemodynamic …
central role in maintaining vascular integrity and homeostasis in response to hemodynamic …
Microfluidic organ-chips and stem cell models in the fight against COVID-19
S Satta, SJ Rockwood, K Wang, S Wang… - Circulation …, 2023 - Am Heart Assoc
SARS-CoV-2, the virus underlying COVID-19, has now been recognized to cause
multiorgan disease with a systemic effect on the host. To effectively combat SARS-CoV-2 …
multiorgan disease with a systemic effect on the host. To effectively combat SARS-CoV-2 …
Targeting cell adhesion molecules with nanoparticles using in vivo and flow-based in vitro models of atherosclerosis
K Khodabandehlou, JJ Masehi-Lano… - Experimental …, 2017 - journals.sagepub.com
Atherosclerosis is a leading cause of death worldwide; in addition to lipid dysfunction,
chronic arterial wall inflammation is a key component of atherosclerosis. Techniques that …
chronic arterial wall inflammation is a key component of atherosclerosis. Techniques that …
Microvascular endothelial cells migrate upstream and align against the shear stress field created by impinging flow
At present, little is known about how endothelial cells respond to spatial variations in fluid
shear stress such as those that occur locally during embryonic development, at heart valve …
shear stress such as those that occur locally during embryonic development, at heart valve …
Numerical solution of the Pulsatile, non-Newtonian and turbulent blood flow in a patient specific elastic carotid artery
J Moradicheghamahi, J Sadeghiseraji… - International Journal of …, 2019 - Elsevier
The risk factor increases at the carotid bifurcation as a result of the changes in the flow of
blood and phenomena such as flow separation, the rotational flow, and the effects of the …
blood and phenomena such as flow separation, the rotational flow, and the effects of the …
Physiologic flow-conditioning limits vascular dysfunction in engineered human capillaries
Hemodynamics play a central role in the health and disease of the coronary and peripheral
vascular systems. Vessel-lining endothelial cells are known mechanosensors, responding to …
vascular systems. Vessel-lining endothelial cells are known mechanosensors, responding to …