Oxygen homeostasis represents an organizing principle for understanding metazoan
evolution, development, physiology, and pathobiology. The hypoxia-inducible factors (HIFs) …

As the aging population in developed countries is growing in both numbers and percentage,
the medical, social, and economic burdens posed by nonhealing wounds are increasing …

Multilayered skin substitutes comprising allogeneic cells have been tested for the treatment
of nonhealing cutaneous ulcers. However, such nonnative skin grafts fail to permanently …

The incidence of chronic wounds is increased among older adults, and the impact of chronic
wounds on quality of life is particularly profound in this population. It is well established that …

Diabetic foot ulceration (DFU) is a chronic complication of diabetes that is characterized by
impaired wound healing in the lower extremities. DFU remains a major clinical challenge …

Multipotent mesenchymal stem cells have recently emerged as an attractive cell type for the
treatment of diabetes-associated wounds. The purpose of this study was to examine the …

Chronic systemic hypertension causes cardiac pressure overload leading to increased
myocardial O2 consumption. Hypoxia-inducible factor 1 (HIF-1) is a master regulator of O2 …

Diabetic nonhealing ulcers are the leading cause of nontraumatic amputations. An
increased cancer risk has been found in patients treated with current therapies such as …

Aging is one of the hottest topics in biomedical research. Advances in research and
medicine have helped to preserve human health, leading to an extension of life expectancy …

In patients with chronic wounds, autologous tissue repair is often not sufficient to heal the
wound. These patients might benefit from regenerative medicine or the implantation of a …