Effects of DNA methylation on gene expression and phenotypic traits in cattle: A review
J Zhang, H Sheng, C Hu, F Li, B Cai, Y Ma… - International Journal of …, 2023 - mdpi.com
Gene expression in cells is determined by the epigenetic state of chromatin. Therefore, the
study of epigenetic changes is very important to understand the regulatory mechanism of …
study of epigenetic changes is very important to understand the regulatory mechanism of …
A mammalian methylation array for profiling methylation levels at conserved sequences
A Arneson, A Haghani, MJ Thompson… - Nature …, 2022 - nature.com
Infinium methylation arrays are not available for the vast majority of non-human mammals.
Moreover, even if species-specific arrays were available, probe differences between them …
Moreover, even if species-specific arrays were available, probe differences between them …
The epigenetics of gametes and early embryos and potential long-range consequences in livestock species—filling in the picture with epigenomic analyses
The epigenome is dynamic and forged by epigenetic mechanisms, such as DNA
methylation, histone modifications, chromatin remodeling, and non-coding RNA species …
methylation, histone modifications, chromatin remodeling, and non-coding RNA species …
Assembly of a pangenome for global cattle reveals missing sequences and novel structural variations, providing new insights into their diversity and evolutionary …
Y Zhou, L Yang, X Han, J Han, Y Hu, F Li… - Genome …, 2022 - genome.cshlp.org
A cattle pangenome representation was created based on the genome sequences of 898
cattle representing 57 breeds. The pangenome identified 83 Mb of sequence not found in …
cattle representing 57 breeds. The pangenome identified 83 Mb of sequence not found in …
Comparative analysis of genome-scale, base-resolution DNA methylation profiles across 580 animal species
J Klughammer, D Romanovskaia, A Nemc… - Nature …, 2023 - nature.com
Methylation of cytosines is a prototypic epigenetic modification of the DNA. It has been
implicated in various regulatory mechanisms across the animal kingdom and particularly in …
implicated in various regulatory mechanisms across the animal kingdom and particularly in …
Evolutionary epigenomic analyses in mammalian early embryos reveal species-specific innovations and conserved principles of imprinting
While mouse remains the most popular model, the conservation of parental-to-embryonic
epigenetic transition across mammals is poorly defined. Through analysis of oocytes and …
epigenetic transition across mammals is poorly defined. Through analysis of oocytes and …
Ruminant-specific retrotransposons shape regulatory evolution of bovine immunity
Cattle are an important livestock species, and mapping the genomic architecture of
agriculturally relevant traits such as disease susceptibility is a major challenge in the bovine …
agriculturally relevant traits such as disease susceptibility is a major challenge in the bovine …
Molecular adaptations in response to exercise training are associated with tissue-specific transcriptomic and epigenomic signatures
Regular exercise has many physical and brain health benefits, yet the molecular
mechanisms mediating exercise effects across tissues remain poorly understood. Here we …
mechanisms mediating exercise effects across tissues remain poorly understood. Here we …
Comparative epigenomics reveals the impact of ruminant-specific regulatory elements on complex traits
S Chen, S Liu, S Shi, Y Jiang, M Cao, Y Tang, W Li… - BMC biology, 2022 - Springer
Background Insights into the genetic basis of complex traits and disease in both human and
livestock species have been achieved over the past decade through detection of genetic …
livestock species have been achieved over the past decade through detection of genetic …
Large-scale integration of the non-coding RNAs with DNA methylation in human cancers
Characterizing influences of DNA methylation (DNAm) on non-coding RNAs (ncRNAs) is
important to understand the mechanisms of gene regulation and cancer outcome. In our …
important to understand the mechanisms of gene regulation and cancer outcome. In our …