Signaling pathways play critical roles in executing and controlling important biological
processes within cells. Cells/organisms trigger appropriate signal transduction pathways in …

ATPase family AAA domain-containing protein 2 (ATAD2) has been widely reported to be a
new emerging oncogene that is closely associated with epigenetic modifications in human …

Abstract Background The Hippo pathway is crucial in organ size control and tumorigenesis.
Dysregulation of the Hippo/YAP axis is commonly observed in gastric cancer, while effective …

This study investigates the role of integrin β4 (ITGB4) and stemness-associated factor SOX2
in platinum resistance in lung squamous cell carcinoma (LUSC). The expression of SOX2 …

Simple Summary Retrospective studies of common malignancies such as head and neck
cancer often report lower incidence and/or better outcomes for patients incidentally treated …

Oral squamous cell carcinoma (OSCC) accounts for around 90% of all oral cancers and is
the eighth most common cancer worldwide. Despite progress in managing OSCC, the …

As a member of BET (bromodomain and extra-terminal) protein family, BRD4 (bromodomain-
containing protein 4) is a chromatin-associated protein that interacts with acetylated histones …

Specific cell states in metazoans are established by the symphony of gene expression
programs that necessitate intricate synergic interactions between transcription factors and …

Tobacco and alcohol are risk factors for human papillomavirus–negative head and neck
squamous cell carcinoma (HPV− HNSCC), which arises from the mucosal epithelium of the …

Abstract FAT atypical cadherin 1 (FAT1) is among the most frequently mutated genes in
many types of cancer. Its highest mutation rate is found in head and neck squamous cell …