ATP-binding cassette transporter B1 (ABCB1; P-glycoprotein; multidrug resistance protein 1)
is an adenosine triphosphate (ATP)-dependent efflux transporter located in the plasma …

The final therapeutic effect of a drug candidate, which is directed to a specific molecular
target strongly depends on its absorption, distribution, metabolism and excretion (ADME) …

Aims This study aimed to develop a population pharmacokinetic model for quantitative
evaluation of the influence of genetic variants in metabolic enzymes and transporters on …

Epilepsy is one of the most frequent chronic neurologic disorders that affects nearly 1% of
the population worldwide, especially in developing countries. Currently, several antiepileptic …

As a chronic brain disease, epilepsy affects~ 50 million people worldwide. The traditional
antiepileptic drugs (AEDs) are widely applied but showing various problems. Although the …

Background Lamotrigine is an antiseizure drug (ASD) which was approved by the US Food
and Drug Administration in 1994 to treat focal (partial) seizures, primary generalized tonic …

Evaluating genes involved in the pharmacodynamics and pharmacokinetics of epilepsy
drugs is critical to better understand pharmacoresistant epilepsy. We reviewed the …

Epilepsy is a serious neurological disorder that affects more than 60 million people
worldwide. Intractable epilepsy (IE) refers to approximately 20%–30% of epileptic patients …

Lamotrigine (LTG) is commonly used to control seizure in epilepsy patients and with
referenced therapeutic windows in clinical practice. This study is to identify and characterize …

Objective To evaluate the impact of maternal UGT1A4 and UGT2B7 genetic polymorphisms
and sex of foetus on gestation-induced changes in lamotrigine (LTG) clearance during …