G protein‐coupled receptors (GPCRs) and heterotrimeric G proteins play central roles in a
diverse array of cellular processes. As such, dysregulation of GPCRs and their coupled …

G protein-coupled receptors (GPCRs) belong to a superfamily of cell surface signalling
proteins that have a pivotal role in many physiological functions and in multiple diseases …

Melanoma treatment with the BRAF V600E inhibitor vemurafenib provides therapeutic
benefits but the common emergence of drug resistance remains a challenge. We generated …

Plexin transmembrane receptors and their semaphorin ligands, as well as their co-receptors
(Neuropilin, Integrin, VEGFR2, ErbB2, and Met kinase) are emerging as key regulatory …

G12 proteins comprise a subfamily of G-alpha subunits of heterotrimeric GTP-binding
proteins (G proteins) that link specific cell surface G protein-coupled receptors (GPCRs) to …

The semaphorins, discovered over 20 years ago, are a large family of secreted or
transmembrane and glycophosphatidylinositol-anchored proteins initially identified as axon …

Cancer progression and metastasis are processes that involve significant cellular changes.
Many of these changes include alterations in the activity of the Rho GTPase family of …

Tripartite motif-containing protein 65 (TRIM65) is an E3 ubiquitin ligase and a critical
regulator of a variety of cellular processes as well as tumor progression. Therefore, more …

Gα13 and Gα12, encoded by the GNA13 and GNA12 genes, respectively, are members of
the G12 family of Gα proteins that, along with their associated Gβγ subunits, mediate …

Tumor cell migration is a well-orchestrated multistep process that drives cancer
development and metastasis. Previous data indicated that CD146 expression correlates with …