Publisher Summary This chapter discusses the changes in membrane properties associated
with cellular aging. The change observed during cellular senescence suggesting an …

Publisher Summary Most researchers in the field of aging would agree that there is probably
no single cause of senescence at either the cellular or the organismic level. Research has …

Indirect immunoflourescence was used to investigate the production of a fibrillar fibronectin
matrix by human diploid fibroblasts (IMR-90) as cells progress through their in vitro lifespan …

Fibronectin was measured in early and late passaged human skin fibroblasts utilizing
immunoprecipitation and polyacrylamide gel electrophoresis. A progressive increase in the …

A cDNA library was constructed from poly (A)+ RNA derived from late passage WI-38 cells
and differentially screened with cDNA probes from early and late passage cells. From a …

Attachment, spreading, and microfilament reorganization have been evaluated in human
dermal reticular fibroblasts isolated from the inner, upper aspect of the arm of a newborn …

The cytoskeletons of early and late passage IMR-90 human diploid fibroblasts have been
directly imaged in replicas of Triton X-100 extracted cells during spreading following …

The study of human genetic disorders known as premature aging syndromes may provide
insight into the mechanisms of cellular senescence. These diseases are clinically …

The nuclear morphology of WI-38 cells plated on increasing thicknesses of the polymer, poly-
2-hydroxyethylmethacrylate, was studied. Changes in nuclear morphometry were found to …

The alterations in surface morphology in human retinal pigment epithelium in explant culture
was studied by scanning electron microscopy. After 14 days in culture, large areas of the …