Ion mobility mass spectrometry (IM-MS) for structural biology: insights gained by measuring mass, charge, and collision cross section

E Christofi, P Barran - Chemical Reviews, 2023 - ACS Publications
The investigation of macromolecular biomolecules with ion mobility mass spectrometry (IM-
MS) techniques has provided substantial insights into the field of structural biology over the …

Characterizing endogenous protein complexes with biological mass spectrometry

R Rogawski, M Sharon - Chemical reviews, 2021 - ACS Publications
Biological mass spectrometry (MS) encompasses a range of methods for characterizing
proteins and other biomolecules. MS is uniquely powerful for the structural analysis of …

Collision cross-section calibration strategy for lipid measurements in SLIM-based high-resolution ion mobility

BS Rose, JC May, AR Reardon… - Journal of the American …, 2022 - ACS Publications
Structures for lossless ion manipulation-based high-resolution ion mobility (HRIM) interfaced
with mass spectrometry has emerged as a powerful tool for the separation and analysis of …

A preprocessing tool for enhanced ion mobility–mass spectrometry-based omics workflows

A Bilbao, BC Gibbons, SM Stow, JE Kyle… - Journal of proteome …, 2021 - ACS Publications
The ability to improve the data quality of ion mobility–mass spectrometry (IM-MS)
measurements is of great importance for enabling modular and efficient computational …

Collision cross section measurement and prediction methods in omics

KY Kartowikromo, OE Olajide… - Journal of mass …, 2023 - Wiley Online Library
Omics studies such as metabolomics, lipidomics, and proteomics have become important for
understanding the mechanisms in living organisms. However, the compounds detected are …

Computational tools and algorithms for ion mobility spectrometry‐mass spectrometry

DH Ross, H Bhotika, X Zheng, RD Smith… - …, 2024 - Wiley Online Library
Ion mobility spectrometry‐mass spectrometry (IMS‐MS or IM‐MS) is a powerful analytical
technique that combines the gas‐phase separation capabilities of IM with the identification …

DEIMoS: an open-source tool for processing high-dimensional mass spectrometry data

SM Colby, CH Chang, JL Bade, JR Nunez… - Analytical …, 2022 - ACS Publications
We present DEIMoS: Data Extraction for Integrated Multidimensional Spectrometry, a Python
application programming interface (API) and command-line tool for high-dimensional mass …

Recent developments in data acquisition, treatment and analysis with ion mobility‐mass spectrometry for lipidomics

M Moran‐Garrido, SM Camunas‐Alberca… - …, 2022 - Wiley Online Library
Lipids are involved in many biological processes and their study is constantly increasing. To
identify a lipid among thousand requires of reliable methods and techniques. Ion Mobility …

Insights and prospects for ion mobility-mass spectrometry in clinical chemistry

DC Koomen, JC May, JA McLean - Expert review of proteomics, 2022 - Taylor & Francis
Introduction Ion mobility-mass spectrometry is an emerging technology in the clinical setting
for high throughput and high confidence molecular characterization from complex biological …

Transition Metal Ion FRET-Based Probe to Study Cu (II)-Mediated Amyloid-β Ligand Binding

R Wu, D Svingou, JB Metternich… - Journal of the …, 2024 - ACS Publications
Recent therapeutic strategies suggest that small peptides can act as aggregation inhibitors
of monomeric amyloid-β (Αβ) by inducing structural rearrangements upon complexation …