Leishmaniasis (visceral and cutaneous), Chagas disease and human African
trypanosomiasis cause substantial death and morbidity, particularly in low-and middle …

Chagas disease (CD) is a parasitic, systemic, chronic, and often fatal illness caused by
infection with the protozoan Trypanosoma cruzi. The World Health Organization classifies …

Summary Background Current treatment for Chagas disease with the only available drugs,
benznidazole or nifurtimox, has substantial limitations, including long treatment duration and …

Chagas disease is an anthropozoonosis from the American continent that has spread from
its original boundaries through migration. It is caused by the protozoan Trypanosoma cruzi …

Chagas disease (CD) is caused by the protozoan parasite Trypanosoma cruzi that infects a
broad range of triatomines and mammalian species, including man. It afflicts 8 million …

Background Chagas disease is a major neglected vector-borne disease. In this study, we
investigated the safety and efficacy of three oral E1224 (a water-soluble ravuconazole …

Chagas disease (CD), also known as American trypanosomiasis, is a multisystemic disorder
that can affect the cardiovascular, digestive, and central nervous systems. 1 CD is caused by …

Chagas disease, caused by Trypanosoma cruzi, is treated with only two drugs;
benznidazole and nifurtimox. These drugs have some disadvantages, including their …

The ability of the Chagas disease agent Trypanosoma cruzi to resist extended in vivo
exposure to highly effective trypanocidal compounds prompted us to explore the potential for …

Trypanosoma cruzi (T. cruzi) infection is endemic in Latin America and is becoming a
worldwide health burden. It may lead to heterogeneous phenotypes. Early diagnosis of T …