The mitochondrial calcium uniporter is an evolutionarily conserved calcium channel, and its
biophysical properties and relevance to cell death, bioenergetics and signalling have been …

The goal of this review is to present a comprehensive survey of the many intriguing facets of
creatine (Cr) and creatinine metabolism, encompassing the pathways and regulation of Cr …

Intracellular energy distribution has attracted much interest and has been proposed to occur
in skeletal muscle via metabolite-facilitated diffusion,; however, genetic evidence suggests …

Mitochondrial calcium has been postulated to regulate a wide range of processes from
bioenergetics to cell death. Here, we characterize a mouse model that lacks expression of …

Perturbations in metabolic processes are associated with diseases such as obesity, type 2
diabetes mellitus, certain infections and some cancers. A resurgence of interest in creatine …

The pleiotropic effects of creatine (Cr) are based mostly on the functions of the enzyme
creatine kinase (CK) and its high-energy product phosphocreatine (PCr). Multidisciplinary …

Understanding the genetic architecture of athletic performance is an important step in the
development of methods for talent identification in sport. Research concerned with …

A variety of cytokines activate receptor-associated members of the Janus family of protein
tyrosine kinases (Jaks). To assess the role of Jak2, we have derived Jak2-deficient mice …

SIGNAL transducers and activators of transcription (STATs) are activated by tyrosine
phosphorylation in response to cytokines and mediate many of their functional responses1 …

Background In patients with heart failure due to dilated cardiomyopathy, cardiac energy
metabolism is impaired, as indicated by a reduction of the myocardial phosphocreatine-to …