RTS, S/AS01 vaccine (Mosquirix™): an overview

MB Laurens - Human vaccines & immunotherapeutics, 2020 - Taylor & Francis
Malaria is an illness caused by Plasmodium parasites transmitted to humans by infected
mosquitoes. Of the five species that infect humans, P. falciparum exacts the highest toll in …

New developments in anti-malarial target candidate and product profiles

JN Burrows, S Duparc, WE Gutteridge… - Malaria journal, 2017 - Springer
A decade of discovery and development of new anti-malarial medicines has led to a
renewed focus on malaria elimination and eradication. Changes in the way new anti …

Adjuvant system AS01: helping to overcome the challenges of modern vaccines

AM Didierlaurent, B Laupèze, A Di Pasquale… - Expert review of …, 2017 - Taylor & Francis
Introduction: Adjuvants are used to improve vaccine immunogenicity and efficacy by
enhancing antigen presentation to antigen-specific immune cells with the aim to confer long …

Reflections on the 2021 World Malaria Report and the future of malaria control

A Monroe, NA Williams, S Ogoma, C Karema, F Okumu - Malaria Journal, 2022 - Springer
Abstract The World Malaria Report, released in December 2021, reflects the unique
challenges currently facing the global malaria community. The report showed the …

Toll‐like receptors: the swiss army knife of immunity and vaccine development

JK Dowling, A Mansell - Clinical & translational immunology, 2016 - Wiley Online Library
Innate immune cells have a critical role in defense against infection and disease. Central to
this is the broad specificity with which they can detect pathogen‐associated patterns and …

malERA: an updated research agenda for malaria elimination and eradication

RN Rabinovich, C Drakeley, AA Djimde, BF Hall… - PLoS …, 2017 - journals.plos.org
Achieving a malaria-free world presents exciting scientific challenges as well as
overwhelming health, equity, and economic benefits. WHO and countries are setting …

Benefits and risks of the Sanofi-Pasteur dengue vaccine: Modeling optimal deployment

NM Ferguson, I Rodríguez-Barraquer, I Dorigatti… - Science, 2016 - science.org
The first approved dengue vaccine has now been licensed in six countries. We propose that
this live attenuated vaccine acts like a silent natural infection in priming or boosting host …

The RTS, S malaria vaccine: Current impact and foundation for the future

JG Beeson, L Kurtovic, C Valim, KP Asante… - Science Translational …, 2022 - science.org
The RTS, S vaccine has recently been recommended for implementation as a childhood
vaccine in regions with moderate-to-high malaria transmission. We discuss mechanisms of …

Mosquirix™ RTS, S/AS01 vaccine development, immunogenicity, and efficacy

AY Nadeem, A Shehzad, SU Islam, EA Al-Suhaimi… - Vaccines, 2022 - mdpi.com
Malaria is a parasitic infection caused by bites from Plasmodium falciparum (P. falciparum)-
infected mosquitoes with a present scale of symptoms ranging from moderate fever to …

Impact of mosquito gene drive on malaria elimination in a computational model with explicit spatial and temporal dynamics

PA Eckhoff, EA Wenger… - Proceedings of the …, 2017 - National Acad Sciences
The renewed effort to eliminate malaria and permanently remove its tremendous burden
highlights questions of what combination of tools would be sufficient in various settings and …