Alzheimer disease (AD) is characterized by wide heterogeneity in cognitive and behavioural
syndromes, risk factors and pathophysiological mechanisms. Addressing this phenotypic …

Apolipoprotein E (ApoE) is a multifunctional protein involved in lipid transport and
lipoprotein metabolism, mediating lipid distribution/redistribution in tissues and cells. It can …

Brain-derived neurotrophic factor (BDNF) has a neurotrophic support on neuron of central
nervous system (CNS) and is a key molecule in the maintenance of synaptic plasticity and …

Alzheimer's disease (AD) is an increasingly prevalent, fatal neurodegenerative disease that
has proven resistant, thus far, to all attempts to prevent it, forestall it, or slow its progression …

Alzheimer's disease (AD) is a common neurodegenerative disorder that presents with
cognitive impairment and behavioral disturbance. Approximately 5.5 million people in the …

Background APOE genotype is the greatest genetic risk factor for sporadic Alzheimer's
disease (AD). APOE4 increases AD risk up to 12-fold compared to APOE3, an effect that is …

The massive use of chlorpyrifos (CPF) has been associated with an increased prevalence of
neurodevelopmental disorders. Some previous studies have shown that prenatal, but not …

Phosphodiesterase-4 (PDE4) inhibitors enhance memory, increase hippocampal
neurogenesis, and reverse amyloidß (Aß)-induced memory deficits. Here, we examined …

Brain‐derived neurotrophic factor (BDNF) regulates diverse processes such as neuronal
survival, differentiation, and plasticity. Accumulating evidence suggests that molecular …

Despite restrictions on their use, humans are still constantly exposed to organophosphates
(OPs). A huge number of studies have ratified the neurotoxic effects of chlorpyrifos (CPF) …