The fifth edition of the World Health Organization (WHO) classification of urogenital tumours
(WHO “Blue Book”), published in 2022, contains significant revisions. This review …

Abstract The Genitourinary Pathology Society (GUPS) undertook a critical review of the
recent advances in renal neoplasia, particularly focusing on the newly accumulated …

Abstract The Genitourinary Pathology Society (GUPS) reviewed recent advances in renal
neoplasia, particularly post-2016 World Health Organization (WHO) classification, to provide …

Mitochondria play a key role in both health and disease. Their function is not limited to
energy production but serves multiple mechanisms varying from iron and calcium …

Otto Warburg hypothesized that some cancer cells reprogram their metabolism, favoring
glucose metabolism by anaerobic glycolysis (Warburg effect) instead of oxidative …

Objective To study the clinical features and identify unique renal neoplasia subtypes and
their prognostic implications in individuals with tuberous sclerosis complex (TSC). Patients …

Fumarate hydratase (FH)–deficient renal cell carcinoma (RCC) is an aggressive, rare
genetic disease affecting the kidney and other organ systems. We constructed a specialized …

Despite the increasing number of newly identified renal neoplasms, the diagnosis of renal
cell carcinoma (RCC) can usually be reached with careful histologic examination and a …

Non-clear cell renal cell carcinomas (nccRCC) represent a highly heterogeneous group of
kidney tumors, consisting of the following subtypes: papillary carcinomas, chromophobe …

Fumarate hydratase-deficient renal cell carcinoma (FH-deficient RCC) is typically
considered a high-grade, aggressive subtype of RCC that frequently arises in the setting of …