Natural killer (NK) cells are major contributors to immunosurveillance and control of tumor
development by inducing apoptosis of malignant cells. Among the main mechanisms …

With the continued failures of both early diagnosis and treatment options for pancreatic
cancer, it is now time to comprehensively evaluate the role of the immune system on the …

Mesenchymal stem cells (MSCs) have attracted great interest in cancer therapy owing to
their tumor-oriented homing capacity and the feasibility of autologous transplantation …

Purpose: We previously reported that small molecule X-linked inhibitor of apoptosis (XIAP)
inhibitors synergize with soluble TRAIL to trigger apoptosis in pancreatic carcinoma cells …

Background Pancreatic ductal adenocarcinoma (PDAC) is one of the most malignant tumors
with a dismal prognosis and no effective conservative therapeutic strategies. Although it is …

Acquired immune evasion is one of the mechanisms that contributes to the dismal prognosis
of cancer. Recently, we observed that different γδ T cell subsets as well as CD8+ αβ T cells …

TNF-related apoptosis-inducing ligand (TRAIL) is a prominent cytokine capable of inducing
apoptosis. It can bind to five different cognate receptors, through which diverse intracellular …

Lung cancer, especially lung adenocarcinoma, is one of the main causes of death
worldwide. Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a primary …

Pancreatic ductal adenocarcinoma (PDAC) is characterized by a dismal prognosis and no
effective conservative therapy exists. Although the F-box protein S-phase kinase associated …

Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), which is capable of
selectively inducing apoptosis of cancer cells, is a potential targeted drug for cancer therapy …