High-fidelity DNA replication is critical for the faithful transmission of genetic information to
daughter cells. Following genotoxic stress, specialized DNA damage tolerance pathways …

Genome instability has been identified as one of the enabling hallmarks in cancer. DNA
damage response (DDR) network is responsible for maintenance of genome integrity in …

DNA replication stress-induced fork arrest represents a significant threat to genomic
integrity. One major mechanism of replication restart involves repriming downstream of the …

PARP inhibitors (PARPi) represent a game-changing treatment for patients with ovarian
cancer with tumors deficient for the homologous recombination (HR) pathway treated with …

The discovery of synthetic lethality as a result of the combined loss of PARP1 and BRCA has
revolutionized the treatment of DNA repair-deficient cancers. With the development of PARP …

Translesion DNA synthesis (TLS) is a DNA damage tolerance pathway utilized by cells to
overcome lesions encountered throughout DNA replication. During replication stress, cancer …

CRISPR Cas9-based screening is a powerful approach for identifying and characterizing
novel drug targets. Here, we elucidate the synthetic lethal mechanism of deubiquitinating …

Recent studies suggest that PARP and POLQ inhibitors confer synthetic lethality in BRCA1-
deficient tumors by accumulation of single-stranded DNA (ssDNA) gaps at replication forks …

Abstract Changes in gene expression in lung epithelial cells are detected in cancer tissues
during exposure to pollutants, highlighting the importance of gene‐environmental …

Defects in DNA repair pathways play a pivotal role in tumor evolution and resistance to
therapy. At the same time, they create vulnerabilities that render tumors dependent on the …