A decline in mitochondrial quality and activity has been associated with normal aging and
correlated with the development of a wide range of age-related diseases. Here, we review …

Mitochondria participate in crucial cellular processes such as energy harvesting and
intermediate metabolism. Although mitochondria possess their own genome—a vestige of …

Coenzyme Q (CoQ, ubiquinone) is a redox-active lipid produced across all domains of life
that functions in electron transport and oxidative phosphorylation and whose deficiency …

Mitochondria are organelles central to myriad cellular processes. To maintain mitochondrial
health, various processes co-operate at both the molecular and organelle level. At the …

Mitochondria, the cell's major energy producers, also act as signaling hubs, interacting with
other organelles both directly and indirectly. Despite having its own circular genome, the …

Mitohormesis is a term used to define a biological response where the induction of a
reduced amount of mitochondrial stress leads to an increment in health and viability within a …

This chapter focuses on the introduction of molecular signaling pathways involved in
regulating the toxicity of environmental toxicants or stresses in Caenorhabditis elegans …

Hormesis is a process whereby exposure to a low dose of a potentially harmful stressor
promotes adaptive changes to the cell that enables it to better tolerate subsequent stress. In …

Mitochondria drive cellular adaptation to stress by retro-communicating with the nucleus.
This process is known as mitochondrial retrograde response (MRR) and is induced by …

Model organisms have provided fundamental evidence that aging can be delayed and
longevity extended. These findings gave rise to a new era in aging research aimed at …