Metal-free multicomponent syntheses of pyridines

C Allais, JM Grassot, J Rodriguez… - Chemical …, 2014 - ACS Publications
They react according to a succession of mono-or bimolecular processes to form at the end
one product that incorporates important portions and functionalities of the starting materials …

Chemistry of α-oxoesters: a powerful tool for the synthesis of heterocycles

B Eftekhari-Sis, M Zirak - Chemical reviews, 2015 - ACS Publications
Heterocycles are an important class of organic compounds accounting for nearly one-third of
the past decade's publications, which are in the field of heterocyclic chemistry. In fact, two …

Recent strategies for the synthesis of pyridine derivatives

MD Hill - Chemistry–A European Journal, 2010 - Wiley Online Library
Recent advances in pyridine synthesis are described. Modification of traditional
condensation strategies continues to be a recurrent theme in contemporary literature …

Modular pyridine synthesis from oximes and enals through synergistic copper/iminium catalysis

Y Wei, N Yoshikai - Journal of the American Chemical Society, 2013 - ACS Publications
We describe here a [3+ 3]-type condensation reaction of O-acetyl ketoximes and α, β-
unsaturated aldehydes that is synergistically catalyzed by a copper (I) salt and a secondary …

[HTML][HTML] Multicomponent reactions: A simple and efficient route to heterocyclic phosphonates

M Haji - Beilstein journal of organic chemistry, 2016 - beilstein-journals.org
Multicomponent reactions (MCRs) are one of the most important processes for the
preparation of highly functionalized organic compounds in modern synthetic chemistry. As …

One-pot reactions for modular synthesis of polysubstituted and fused pyridines

Z Song, X Huang, W Yi, W Zhang - Organic letters, 2016 - ACS Publications
A 2-fluoro-1, 3-dicarbonyl-initiated one-pot Michael addition/[5+ 1] annulation/
dehydrofluorinative aromatization reaction sequence is introduced for regioselective …

Highly diastereo-and enantioselective organocatalytic michael addition of α-ketoamides to nitroalkenes

O Basle, W Raimondi, MMS Duque, D Bonne… - Organic …, 2010 - ACS Publications
The first organocatalytic enantio-and diastereoselective conjugate addition of α-ketoamides
to nitroalkenes has been achieved using a bifunctional amino thiourea catalyst. In this new …

Nature-inspired remodeling of (aza)indoles to meta-aminoaryl nicotinates for late-stage conjugation of vitamin B3 to (hetero)arylamines

BV Varun, K Vaithegi, S Yi, SB Park - Nature Communications, 2020 - nature.com
Despite the availability of numerous routes to substituted nicotinates based on the
Bohlmann–Rahtz pyridine synthesis, the existing methods have several limitations, such as …

N-Silylenamines as Reactive Intermediates: Hydroamination for the Modular Synthesis of Selectively Substituted Pyridines

EKJ Lui, D Hergesell, LL Schafer - Organic letters, 2018 - ACS Publications
A modular and selective synthesis of mono-, di-, tri-, tetra-, and pentasubstituted pyridines is
reported. Hydroamination of alkynes with N-silylamine using a bis (amidate) bis (amido) …

Regioselective access to di-and trisubstituted pyridines via a metal-oxidant-solvent-free domino reaction involving 3-chloropropiophenones

AK Patel, SS Rathor, S Samanta - Organic & Biomolecular Chemistry, 2022 - pubs.rsc.org
A remarkable metal-oxidant-solvent-and base-free domino route for regioselective access to
a wide range of 2, 4-di-and 2, 3, 4/6-trisubstituted pyridines including carbo-and heterocyclic …