Cyclooxygenases and prostaglandins in tumor immunology and microenvironment of gastrointestinal cancer

D Wang, CS Cabalag, NJ Clemons, RN DuBois - Gastroenterology, 2021 - Elsevier
Chronic inflammation is a known risk factor for gastrointestinal cancer. The evidence that
nonsteroidal anti-inflammatory drugs suppress the incidence, growth, and metastasis of …

Inflammation-induced tryptophan breakdown is related with anemia, fatigue, and depression in cancer

L Lanser, P Kink, EM Egger, W Willenbacher… - Frontiers in …, 2020 - frontiersin.org
Many patients with cancer suffer from anemia, depression, and an impaired quality of life
(QoL). These patients often also show decreased plasma tryptophan levels and increased …

[HTML][HTML] Combined chemotherapy with cyclooxygenase-2 (COX-2) inhibitors in treating human cancers: Recent advancement

S Li, M Jiang, L Wang, S Yu - Biomedicine & Pharmacotherapy, 2020 - Elsevier
Chemotherapy with a single chemotherapeutic agent or a combined chemotherapeutic
regimen is the clinically standardized treatment for almost all human cancers. Upregulated …

Drug repurposing for cancer therapy

Y Xia, M Sun, H Huang, WL Jin - Signal Transduction and Targeted …, 2024 - nature.com
Cancer, a complex and multifactorial disease, presents a significant challenge to global
health. Despite significant advances in surgical, radiotherapeutic and immunological …

The impact of core technological capabilities of high-tech industry on sustainable competitive advantage

B Feng, K Sun, M Chen, T Gao - Sustainability, 2020 - mdpi.com
The market competitiveness and sustainable operation of an enterprise are closely
correlated with the support of high-tech core technologies in the enterprise. This study first …

Targeting inflammation as cancer therapy

M Wang, S Chen, X He, Y Yuan, X Wei - Journal of Hematology & …, 2024 - Springer
Inflammation has accompanied human beings since the emergence of wounds and
infections. In the past decades, numerous efforts have been undertaken to explore the …

[HTML][HTML] The inflammatory profile of the tumor microenvironment, orchestrated by cyclooxygenase-2, promotes epithelial-mesenchymal transition

F Gómez-Valenzuela, E Escobar… - Frontiers in …, 2021 - frontiersin.org
The tumor microenvironment (TME) corresponds to a complex and dynamic interconnection
between the extracellular matrix and malignant cells and their surrounding stroma …

Chemopreventive potential of caryophyllane sesquiterpenes: An overview of preliminary evidence

A Di Sotto, R Mancinelli, M Gullì, M Eufemi… - Cancers, 2020 - mdpi.com
Simple Summary Caryophyllane sesquiterpenes are unique natural compounds widely
occurring in nature, especially in plant essential oils, that are characterized by multiple …

[HTML][HTML] Platelets and metastasis: new implications of an old interplay

S Lucotti, RJ Muschel - Frontiers in oncology, 2020 - frontiersin.org
During the process of hematogenous metastasis, tumor cells interact with platelets and their
precursors megakaryocytes, providing a selection driver for the metastatic phenotype …

Association of quality-of-life outcomes in cancer drug trials with survival outcomes and drug class

JN Samuel, CM Booth, E Eisenhauer… - JAMA …, 2022 - jamanetwork.com
Importance Although quality of life (QOL) is an important clinical end point, cancer drugs are
often approved based on overall survival (OS) or putative surrogate end points such as …