Vaccine technologies and platforms for infectious diseases: Current progress, challenges, and opportunities

M Ghattas, G Dwivedi, M Lavertu, MG Alameh - Vaccines, 2021 - mdpi.com
Vaccination is a key component of public health policy with demonstrated cost-effective
benefits in protecting both human and animal populations. Vaccines can be manufactured …

Effect of rotavirus genetic diversity on vaccine impact

A Sadiq, N Bostan, J Khan… - Reviews in Medical …, 2022 - Wiley Online Library
Group A rotaviruses (RVAs) are the leading cause of gastroenteritis, causing 0.2 million
deaths and several million hospitalisations globally each year. Four rotavirus vaccines …

Natural SARS-CoV-2 infection affects neutralizing activity in saliva of vaccinees

M Garziano, O Utyro, M Poliseno… - Frontiers in …, 2022 - frontiersin.org
Background SARS-CoV-2 transmission mainly occurs through exposure of the upper airway
mucosa to infected secretions such as saliva, which are excreted by an infected person …

Rotavirus as an expression platform of domains of the SARS-CoV-2 spike protein

AA Philip, JT Patton - Vaccines, 2021 - mdpi.com
Among vaccines administered to children are those targeting rotavirus, a segmented double-
stranded RNA virus that represents a major cause of severe gastroenteritis. To explore the …

Recombinant rotavirus expressing the glycosylated S1 protein of SARS-CoV-2

AA Philip, S Hu, J Dai, JT Patton - Journal of General …, 2023 - microbiologyresearch.org
Reverse genetic systems have been used to introduce heterologous sequences into the
rotavirus segmented double-stranded (ds) RNA genome, enabling the generation of …

Vaccinomics Approach for Multi-Epitope Vaccine Design against Group A Rotavirus Using VP4 and VP7 Proteins

M Usman, A Ayub, S Habib, MS Rana, Z Rehman… - Vaccines, 2023 - mdpi.com
Rotavirus A is the most common cause of Acute Gastroenteritis globally among children< 5
years of age. Due to a segmented genome, there is a high frequency of genetic …

Multimodal profiling reveals tissue-directed signatures of human immune cells altered with age

SB Wells, DB Rainbow, M Mark, PA Szabo, C Ergen… - bioRxiv, 2024 - biorxiv.org
The immune system comprises multiple cell lineages and heterogeneous subsets found in
blood and tissues throughout the body. While human immune responses differ between …

[PDF][PDF] Mathematical modelling of rotavirus disease through efficient methods

A Raza - Computers, Materials and Continua, 2022 - cdn.techscience.cn
The design of evolutionary approaches has a vital role in the recent development of
scientific literature. To tackle highly nonlinear complex problems, nonlinear ordinary …

Assessment of the aetiology of acute gastroenteritis outbreaks in infants reveals rotavirus, noroviruses and adenovirus prevalence and viral coinfections in Nsukka …

VN Chigor, PE Chidebelu, DC Digwo, CB Chigor… - VirusDisease, 2023 - Springer
A better understanding of the aetiology of acute gastroenteritis (AGE) outbreaks in Southeast
Nigeria would help safeguarding public health. This study screened stool samples collected …

Prediction of effectiveness of universal rotavirus vaccination in Southwestern Vietnam based on a dynamic mathematical model

T Lee, JM Kang, JG Ahn, DT Thuy Truong… - Scientific reports, 2024 - nature.com
Vaccinating young children against rotavirus (RV) is a promising preventive strategy against
rotavirus gastroenteritis (RVGE). We evaluated the relative risk reduction of RVGE induced …