The emerging tale of microglia in psychiatric disorders
As the professional phagocytes of the brain, microglia orchestrate the immunological
response and play an increasingly important role in maintaining homeostatic brain functions …
response and play an increasingly important role in maintaining homeostatic brain functions …
Meta-analysis of molecular imaging of translocator protein in major depression
B Eggerstorfer, JH Kim, P Cumming… - Frontiers in molecular …, 2022 - frontiersin.org
Molecular neuroimaging studies provide mounting evidence that neuroinflammation plays a
contributory role in the pathogenesis of major depressive disorder (MDD). This has been the …
contributory role in the pathogenesis of major depressive disorder (MDD). This has been the …
[HTML][HTML] Imaging transcriptomics: Convergent cellular, transcriptomic, and molecular neuroimaging signatures in the healthy adult human brain
The integration of transcriptomic and neuroimaging data," imaging transcriptomics," has
recently emerged to generate hypotheses about potential biological pathways underlying …
recently emerged to generate hypotheses about potential biological pathways underlying …
Higher immune-related gene expression in major depression is independent of CRP levels: results from the BIODEP study
L Sforzini, A Cattaneo, C Ferrari, L Turner… - Translational …, 2023 - nature.com
Compelling evidence demonstrates that some individuals suffering from major depressive
disorder (MDD) exhibit increased levels of inflammation. Most studies focus on inflammation …
disorder (MDD) exhibit increased levels of inflammation. Most studies focus on inflammation …
Suicide and inflammation
JJ Donegan, CB Nemeroff - … , Gut-Brain Axis and Immunity in …, 2023 - Springer
Suicide is a leading cause of death worldwide. Although the neurobiological dysfunction
underlying suicidal behavior remains unclear, recent work suggests that the immune system …
underlying suicidal behavior remains unclear, recent work suggests that the immune system …
Have (R)-[11C]PK11195 challengers fulfilled the promise? A scoping review of clinical TSPO PET studies
Purpose The prototypical TSPO radiotracer (R)-[11C] PK11195 has been used in humans
for more than thirty years to visualize neuroinflammation in several pathologies. Alternative …
for more than thirty years to visualize neuroinflammation in several pathologies. Alternative …
Insulin resistance and body mass index are associated with TSPO PET in cognitively unimpaired elderly
Metabolic risk factors are associated with peripheral low-grade inflammation and an
increased risk for dementia. We evaluated if metabolic risk factors ie insulin resistance, body …
increased risk for dementia. We evaluated if metabolic risk factors ie insulin resistance, body …
[HTML][HTML] Corticostriatal contributions to dysregulated motivated behaviors in stress, depression, and substance use disorders
Coordinated network activity, particularly in circuits arising from the prefrontal cortex
innervating the ventral striatum, is crucial for normal processing of reward-related …
innervating the ventral striatum, is crucial for normal processing of reward-related …
Extra-axial inflammatory signal and its relation to peripheral and central immunity in depression
Although both central and peripheral inflammation have been consistently observed in
depression, the relationship between the two remains obscure. Extra-axial immune cells …
depression, the relationship between the two remains obscure. Extra-axial immune cells …
[HTML][HTML] Interaction between peripheral and central immune markers in clinical high risk for psychosis
Neuroinflammatory events prior to the diagnosis of schizophrenia may play a role in
transition to illness. To date only one in-vivo study has investigated this association between …
transition to illness. To date only one in-vivo study has investigated this association between …