Obstructive sleep apnea (OSA) is a highly prevalent disease, and is traditionally associated
with increased cardiovascular risk. The role of comorbidities in OSA patients has emerged …

Epithelial-mesenchymal transition (EMT) is a cellular biological process involved in
migration of primary cancer cells to secondary sites facilitating metastasis. Besides, EMT …

Hypoxia has been shown to increase the aggressiveness and severity of tumor progression.
Along with chronic and acute hypoxic regions, solid tumors contain regions of cycling …

Adaptation to the loss of O2 is regulated via the activity of hypoxia-inducible factors such as
Hypoxia-Inducible Factor-1 (HIF-1). HIF-1 acts as a main transcriptional mediator in the …

During hypoxic conditions, cells undergo critical adaptive responses that include the up-
regulation of hypoxia-inducible proteins (HIFs) and the induction of the unfolded protein …

Simple Summary The complex signaling networks that different cancers utilize for cell
survival remain poorly understood. A major problem is the complexity of the tumor …

Obstructive sleep apnoea (OSA) is a prevalent disorder associated with increased
cardiovascular, metabolic and neurocognitive morbidity. Recently, an increasing number of …

2. Herold S, Steinmueller M, von Wulffen W, Cakarova L, Pinto R, Pleschka S, et al. Lung
epithelial apoptosis in influenza virus pneumonia: the role of macrophage-expressed TNF …

The purpose of this study was to evaluate whether obstructive sleep apnea (OSA)-related
chronic intermittent hypoxia (CIH) influences lung cancer progression and to elucidate the …

Reduced levels of intratumoural oxygen are associated with hypoxia-induced pro-oncogenic
events such as invasion, metabolic reprogramming, epithelial–mesenchymal transition …