From omics to multi-omics approaches for in-depth analysis of the molecular mechanisms of prostate cancer

E Nevedomskaya, B Haendler - International Journal of Molecular …, 2022 - mdpi.com
Cancer arises following alterations at different cellular levels, including genetic and
epigenetic modifications, transcription and translation dysregulation, as well as metabolic …

A multi-omic analysis reveals the esophageal dysbiosis as the predominant trait of eosinophilic esophagitis

L Massimino, A Barchi, FV Mandarino, S Spanò… - Journal of Translational …, 2023 - Springer
Abstract Background Eosinophilic esophagitis (EoE) is a chronic immune-mediated rare
disease, characterized by esophageal dysfunctions. It is likely to be primarily activated by …

Multi-Omics Mining of lncRNAs with Biological and Clinical Relevance in Cancer

I Salido-Guadarrama, SL Romero-Cordoba… - International Journal of …, 2023 - mdpi.com
In this review, we provide a general overview of the current panorama of mining strategies
for multi-omics data to investigate lncRNAs with an actual or potential role as biological …

A comprehensive review of machine learning techniques for multi-omics data integration: challenges and applications in precision oncology

D Acharya, A Mukhopadhyay - Briefings in Functional Genomics, 2024 - academic.oup.com
Multi-omics data play a crucial role in precision medicine, mainly to understand the diverse
biological interaction between different omics. Machine learning approaches have been …

Computational approaches leveraging integrated connections of multi-omic data toward clinical applications

HC Demirel, MK Arici, N Tuncbag - Molecular omics, 2022 - pubs.rsc.org
In line with the advances in high-throughput technologies, multiple omic datasets have
accumulated to study biological systems and diseases coherently. No single omics data type …

Methods for multi-omic data integration in cancer research

E Hernández-Lemus, S Ochoa - Frontiers in Genetics, 2024 - frontiersin.org
Multi-omics data integration is a term that refers to the process of combining and analyzing
data from different omic experimental sources, such as genomics, transcriptomics …

Serum multi-omics analysis in hindlimb unloading mice model: Insights into systemic molecular changes and potential diagnostic and therapeutic biomarkers

Z Ibrahim, NA Khan, R Qaisar, MA Saleh, R Siddiqui… - Heliyon, 2024 - cell.com
Microgravity, in space travel and prolonged bed rest conditions, induces cardiovascular
deconditioning along with skeletal muscle mass loss and weakness. The findings of …

[HTML][HTML] Mechanisms and technologies in cancer epigenetics

ZA Sherif, OO Ogunwobi, HW Ressom - Frontiers in Oncology, 2025 - pmc.ncbi.nlm.nih.gov
Cancer's epigenetic landscape, a labyrinthine tapestry of molecular modifications, has long
captivated researchers with its profound influence on gene expression and cellular fate. This …

RAF1 promotes lymphatic metastasis of hypopharyngeal carcinoma via regulating LAGE1: an experimental research

Y Li, M Pan, T Lu, D Yu, C Liu, Z Wang, G Hu - Journal of Translational …, 2022 - Springer
Background Lymphatic metastasis was an independent prognostic risk factor for
hypopharyngeal carcinoma and was the main cause of treatment failure. The purpose of this …

Regulatory Effects of SLC7A2‐CPB2 on Lymphangiogenesis: A New Approach to Suppress Lymphatic Metastasis in HNSCC

K Song, Y Li, K Yang, T Lu, M Wang, Z Wang… - Cancer …, 2024 - Wiley Online Library
Background Lymph node metastasis (LNM) is a critical factor affecting the outcomes of head
and neck squamous cell carcinoma (HNSCC) and the main reason for treatment failure. This …