Asthma is chronic inflammation of the airways characterized by airway hyper-
responsiveness, wheezing, cough, and dyspnea. Asthma affects> 350 million people …

Hanahan and Weinberg have proposed 10 organizing principles that enable growth and
metastatic dissemination of cancer cells. These distinctive and complementary capabilities …

Galectins are a family of animal lectins with diverse biological activities. They function both
extracellularly, by interacting with cell-surface and extracellular matrix glycoproteins and …

Galectins are a family of animal lectins that bind β-galactosides. Outside the cell, galectins
bind to cell-surface and extracellular matrix glycans and thereby affect a variety of cellular …

Galectins are widely distributed sugar-binding proteins whose basic specificity for β-
galactosides is conserved by evolutionarily preserved carbohydrate-recognition domains …

Many galectin family members are detected primarily intracellularly in most of the systems
studied, although certain members can be found both inside and outside of cells. Specific …

Galectins are a family of mammalian β-galactoside-binding proteins that positively and
negatively regulate T cell death. Extracellular galectin-1 directly induces death of T cells and …

Recent evidence has implicated galectins and their ligands as master regulators of immune
cell homeostasis. Whereas some members of this family, such as galectin-3, behave as …

Abstract Galectin (Gal)-3, a M r 31,000 member of the β-galactoside-binding protein family,
is a multifunctional protein implicated in a variety of biological functions, including tumor cell …

Abstract Galectin-9 (Gal-9) induced the apoptosis of not only T cell lines but also of other
types of cell lines in a dose-and time-dependent manner. The apoptosis was suppressed by …