Complement-mediated cell death is caused by C5b-9, the membrane attack complex (MAC)
composed of the five complement proteins C5b, C6, C7, C8, and C9. Assembly of the C5b-9 …

Clinical and experimental studies have suggested that complement may play a role in tumor
cytotoxicity. However, the efficiency of complement-mediated tumor cell lysis is hampered by …

The complement system is composed of soluble blood plasma proteins and cell membrane
proteins. A major function of the soluble complement proteins is to bind to and destroy …

Nucleated cells employ several strategies to evade killing by homologous complement. We
studied complement resistance in the human carcinoma cell lines (CA) T47D (mammary) …

The interactions of cancer cells with components of the complement system are highly
complex, leading to an outcome that is either favorable or detrimental to cancer cells …

The number of anti-cancer antibodies in therapy and in clinical trials is increasing gradually
while their curative efficacy remains rather limited due to the resistance of tumor cells to …

In the last quarter of the nineteenth century several workers described the heatlabile lytic
action of serum on bacteria and erythrocytes, and it was these observations which led to the …

Sublytic doses of the membrane attack complex (MAC) of complement are known to exert
multiple stimulatory effects on metabolically active cells. Results presented herewith …

Sublytic doses of complement desensitize cells and make them resistant to lytic complement
doses. This process, named complement-induced protection, requires calcium ion influx …

Resistance of tumor cells to lysis by complement is generally attributed to several protective
mechanisms. The relative impact of these mechanisms in the same tumor cell, however, has …