Vaccines have had a profound impact on the management and prevention of infectious
disease. In addition, the development of vaccines against chronic diseases has attracted …

Over the last two decades, hydrogen sulfide (H2S) has emerged as an endogenous
regulator of a broad range of physiological functions. H2S belongs to the class of molecules …

Cerebral folate deficiency (CFD) syndrome is a neurodevelopmental disorder typically
caused by folate receptor autoantibodies (FRAs) that interfere with folate transport across …

Simple Summary Antibody-Drug Conjugates (ADCs) provide effective anti-cancer
treatments. ADC development requires the identification of appropriate tumour-associated …

During its fourth transporter workshop in 2021, the International Transporter Consortium
(ITC) provided updates on emerging clinically relevant transporters for drug development …

The placenta is a transient organ found in eutherian mammals that evolved primarily to
provide nutrients for the developing fetus. The placenta exchanges a wide array of nutrients …

More evidence is available for maternal intake, absorption, distribution, tissue specific
concentrations, and pregnancy outcomes with folic acid (fortification/supplementation) …

Metformin is the first-line treatment for many people with type 2 diabetes mellitus (T2DM)
and gestational diabetes mellitus (GDM) to maintain glycaemic control. Recent evidence …

DNA methylation, a central component of the epigenetic network is altered in response to
nutritional influences. In one-carbon cycle, folate acts as a one-carbon carrier and vitamin …

Folate can be transported into the cell by the reduced folate carrier (RFC), the proton-
coupled folate transporter (PCFT), or the folate receptor (FR), of which various isoforms exist …