Biodegradable polymeric nanoparticles for therapeutic cancer treatments
Polymeric nanoparticles have tremendous potential to improve the efficacy of therapeutic
cancer treatments by facilitating targeted delivery to a desired site. The physical and …
cancer treatments by facilitating targeted delivery to a desired site. The physical and …
Polymeric nanoparticles in brain cancer therapy: A review of current approaches
Translation of novel therapies for brain cancer into clinical practice is of the utmost
importance as primary brain tumors are responsible for more than 200,000 deaths …
importance as primary brain tumors are responsible for more than 200,000 deaths …
High-throughput and high-content bioassay enables tuning of polyester nanoparticles for cellular uptake, endosomal escape, and systemic in vivo delivery of mRNA
Nanoparticle-based mRNA therapeutics hold great promise, but cellular internalization and
endosomal escape remain key barriers for cytosolic delivery. We developed a dual …
endosomal escape remain key barriers for cytosolic delivery. We developed a dual …
Biodegradable lipophilic polymeric mRNA nanoparticles for ligand-free targeting of splenic dendritic cells for cancer vaccination
E Ben-Akiva, J Karlsson, S Hemmati… - Proceedings of the …, 2023 - National Acad Sciences
Nanoparticle (NP)-based mRNA cancer vaccines hold great promise to realize personalized
cancer treatments. To advance this technology requires delivery formulations for efficient …
cancer treatments. To advance this technology requires delivery formulations for efficient …
Overcoming nonviral gene delivery barriers: perspective and future
A key end goal of gene delivery research is to develop clinically relevant vectors that can be
used to combat elusive diseases such as AIDS. Despite promising engineering strategies …
used to combat elusive diseases such as AIDS. Despite promising engineering strategies …
Carboxylated branched poly (β-amino ester) nanoparticles enable robust cytosolic protein delivery and CRISPR-Cas9 gene editing
Efficient cytosolic protein delivery is necessary to fully realize the potential of protein
therapeutics. Current methods of protein delivery often suffer from low serum tolerance and …
therapeutics. Current methods of protein delivery often suffer from low serum tolerance and …
Biodegradable STING agonist nanoparticles for enhanced cancer immunotherapy
Therapeutic cancer vaccines require adjuvants leading to robust type I interferon and
proinflammatory cytokine responses in the tumor microenvironment to induce an anti-tumor …
proinflammatory cytokine responses in the tumor microenvironment to induce an anti-tumor …
Polymeric vehicles for nucleic acid delivery
AS Piotrowski-Daspit, AC Kauffman… - Advanced drug delivery …, 2020 - Elsevier
Polymeric vehicles are versatile tools for therapeutic gene delivery. Many polymers—when
assembled with nucleic acids into vehicles—can protect the cargo from degradation and …
assembled with nucleic acids into vehicles—can protect the cargo from degradation and …
Poly (β‐Amino Esters): synthesis, formulations, and their biomedical applications
Abstract Poly (β‐amino ester)(abbreviated as PBAE or PAE) refers to a polymer synthesized
from an acrylate and an amine by Michael addition and has properties inherent to tertiary …
from an acrylate and an amine by Michael addition and has properties inherent to tertiary …
Poly (beta-amino ester) s as gene delivery vehicles: challenges and opportunities
Introduction Gene delivery technologies are being developed for an increasing number of
biomedical applications, with delivery vehicles including viruses and non-viral materials …
biomedical applications, with delivery vehicles including viruses and non-viral materials …