Glucocorticoid hormones (cortisol and corticosterone-CORT) are the effector hormones of
the hypothalamic-pituitary-adrenal (HPA) axis neuroendocrine system. CORT is a systemic …

Increasing evidence suggests estrogen and estrogen signaling pathway disturbances
across psychiatric disorders. Estrogens are not only crucial in sexual maturation and …

Inflammatory activation of microglia is a hallmark of several disorders of the central nervous
system. In addition to protecting the brain against inflammatory insults, microglia are …

Hormones regulate homeostasis by communicating through the bloodstream to the body's
organs, including the brain. As homeostatic regulators of brain function, some hormones …

Selective estrogen receptor modulators (SERMs) are structurally different compounds that
interact with intracellular estrogen receptors in target organs as estrogen receptor agonists …

Selective estrogen receptor modulators (SERMs) are synthetic non-steroidal agents which
have varying estrogen agonist and antagonist activities in different tissues, most likely due to …

The nervous system is a target and a source of steroids. Neuroactive steroids are steroids
that target neurons and glial cells. They include hormonal steroids originated in the …

Dementia, osteoporosis, and fragility fractures are chronic diseases, often co-existing in
older adults. These conditions pose severe morbidity, long-term disability, and mortality, with …

This analytical review summarizes literature data and our own research on HSP70-
dependent mechanisms of neuroprotection and discusses potential pharmacological agents …

In the last years there has been a considerable advance in the knowledge on the regulation
of astrocytes by sex steroids under physiological and pathological conditions. By the …