Signal integration by JNK and p38 MAPK pathways in cancer development
EF Wagner, ÁR Nebreda - Nature Reviews Cancer, 2009 - nature.com
Jun N-terminal kinase (JNK) and p38 mitogen-activated protein kinase (MAPK) family
members function in a cell context-specific and cell type-specific manner to integrate signals …
members function in a cell context-specific and cell type-specific manner to integrate signals …
A liver full of JNK: signaling in regulation of cell function and disease pathogenesis, and clinical approaches
c-Jun-N-terminal kinase (JNK) is a mitogen-activated protein kinase family member that is
activated by diverse stimuli, including cytokines (such as tumor necrosis factor and …
activated by diverse stimuli, including cytokines (such as tumor necrosis factor and …
Selective inhibitors for JNK signalling: a potential targeted therapy in cancer
Q Wu, W Wu, V Jacevic, TCC Franca… - Journal of enzyme …, 2020 - Taylor & Francis
Abstract c-Jun N-terminal kinase (JNK) signalling regulates both cancer cell apoptosis and
survival. Emerging evidence show that JNK promoted tumour progression is involved in …
survival. Emerging evidence show that JNK promoted tumour progression is involved in …
JNK signalling in cancer: in need of new, smarter therapeutic targets
The JNKs are master protein kinases that regulate many physiological processes, including
inflammatory responses, morphogenesis, cell proliferation, differentiation, survival and …
inflammatory responses, morphogenesis, cell proliferation, differentiation, survival and …
Discovery of potent and selective covalent inhibitors of JNK
The mitogen-activated kinases JNK1/2/3 are key enzymes in signaling modules that
transduce and integrate extracellular stimuli into coordinated cellular response. Here, we …
transduce and integrate extracellular stimuli into coordinated cellular response. Here, we …
Cellular mechanisms of insulin resistance: role of stress-regulated serine kinases and insulin receptor substrates (IRS) serine phosphorylation
JF Tanti, J Jager - Current opinion in pharmacology, 2009 - Elsevier
Insulin receptor substrates (IRS) serine phosphorylation is a time-controlled physiological
feedback mechanism in insulin signaling that is hijacked by metabolic and inflammatory …
feedback mechanism in insulin signaling that is hijacked by metabolic and inflammatory …
Targeting p38 MAPK pathway for the treatment of Alzheimer's disease
L Munoz, AJ Ammit - Neuropharmacology, 2010 - Elsevier
Accumulating evidence indicates that p38 mitogen-activated protein kinase (MAPK) could
play more than one role in Alzheimer's disease (AD) pathophysiology and that patients …
play more than one role in Alzheimer's disease (AD) pathophysiology and that patients …
JNK pathway signaling: a novel and smarter therapeutic target for various biological diseases
JNK pathway regulates various physiological processes including inflammatory responses,
cell differentiation, cell proliferation, cell death, cell survival and expression of proteins …
cell differentiation, cell proliferation, cell death, cell survival and expression of proteins …
c-Jun N-terminal kinase (JNK) signaling: recent advances and challenges
MA Bogoyevitch, KRW Ngoei, TT Zhao… - … et Biophysica Acta (BBA …, 2010 - Elsevier
c-Jun N-terminal kinases (JNKs), first characterized as stress-activated members of the
mitogen-activated protein kinase (MAPK) family, have become a focus of inhibitor screening …
mitogen-activated protein kinase (MAPK) family, have become a focus of inhibitor screening …
Targeting innate immunity protein kinase signalling in inflammation
Inflammation is an evolutionarily conserved host reaction that is initiated in response to
trauma, tissue damage and infection. It leads to changes in tissue homeostasis and blood …
trauma, tissue damage and infection. It leads to changes in tissue homeostasis and blood …