Single domain antibodies: promising experimental and therapeutic tools in infection and immunity

J Wesolowski, V Alzogaray, J Reyelt, M Unger… - Medical microbiology …, 2009 - Springer
Antibodies are important tools for experimental research and medical applications. Most
antibodies are composed of two heavy and two light chains. Both chains contribute to the …

Single-domain antibodies as building blocks for novel therapeutics

D Saerens, GH Ghassabeh, S Muyldermans - Current opinion in …, 2008 - Elsevier
Antibodies are large and complex molecules, with two identical parts that bind
independently of each other onto the antigen and the third part of the molecule that dictates …

Time-resolved fluorescence immunochromatographic assay developed using two idiotypic nanobodies for rapid, quantitative, and simultaneous detection of aflatoxin …

X Tang, P Li, Q Zhang, Z Zhang, W Zhang… - Analytical …, 2017 - ACS Publications
Aflatoxins and zearalenone (ZEN) are highly common mycotoxins in maize and maize-
based products. This study aimed to report a time-resolved fluorescence …

Production and characterization of biotinylated anti-fenitrothion nanobodies and development of sensitive fluoroimmunoassay

ZJ Chen, YF Zhang, JL Chen, ZS Lin… - Journal of agricultural …, 2022 - ACS Publications
A simple and sensitive fluoroimmunoassay (FIA) based on a heavy-chain antibody (VHH) for
rapid detection of fenitrothion was developed. A VHH library was constructed from an …

Single domain antibodies from llama effectively and specifically block T cell ecto‐ADP‐ribosyltransferase ART2.2 in vivo

F Koch-Nolte, J Reyelt, B Schößow… - The FASEB …, 2007 - Wiley Online Library
The purpose of our study was to develop a tool for blocking the function of a specific
leukocyte ecto‐enzyme in vivo. ART2. 2 is a toxin‐related ecto‐enzyme that transfers the …

Nanobody; an old concept and new vehicle for immunotargeting

F Rahbarizadeh, D Ahmadvand… - Immunological …, 2011 - Taylor & Francis
The use of antibodies in cancer therapy has come a long way since the day Paul Ehrlich
described the concept and Kohler and Milstein devised the hybridoma technology to bring …

Nanobodies effectively modulate the enzymatic activity of CD38 and allow specific imaging of CD38+ tumors in mouse models in vivo

W Fumey, J Koenigsdorf, V Kunick, S Menzel… - Scientific reports, 2017 - nature.com
The cell surface ecto-enzyme CD38 is a promising target antigen for the treatment of
hematological malignancies, as illustrated by the recent approval of daratumumab for the …

Isolation of alpaca anti-idiotypic heavy-chain single-domain antibody for the aflatoxin immunoassay

Y Wang, P Li, Z Majkova, CRS Bever, HJ Kim… - Analytical …, 2013 - ACS Publications
Anti-idiotypic antibodies recognize the antigenic determinants of an antibody, thus they can
be used as surrogate antigens. Single-domain antibodies from camlid heavy-chain …

Application progress of the single domain antibody in medicine

H Tang, Y Gao, J Han - International Journal of Molecular Sciences, 2023 - mdpi.com
The camelid-derived single chain antibody (sdAb), also termed VHH or nanobody, is a
unique, functional heavy (H)-chain antibody (HCAb). In contrast to conventional antibodies …

Survey of the year 2005 commercial optical biosensor literature

RL Rich, DG Myszka - Journal of Molecular Recognition: An …, 2006 - Wiley Online Library
Abstract We identified 1113 articles (103 reviews, 1010 primary research articles) published
in 2005 that describe experiments performed using commercially available optical …