Traumatic brain injury: progress and challenges in prevention, clinical care, and research

AIR Maas, DK Menon, GT Manley, M Abrams… - The Lancet …, 2022 - thelancet.com
Executive summary Traumatic brain injury (TBI) has the highest incidence of all common
neurological disorders, and poses a substantial public health burden. TBI is increasingly …

Chronic traumatic encephalopathy (CTE): criteria for neuropathological diagnosis and relationship to repetitive head impacts

AC McKee, TD Stein, BR Huber, JF Crary… - Acta …, 2023 - Springer
Over the last 17 years, there has been a remarkable increase in scientific research
concerning chronic traumatic encephalopathy (CTE). Since the publication of NINDS–NIBIB …

Mental health consequences of traumatic brain injury

JR Howlett, LD Nelson, MB Stein - Biological psychiatry, 2022 - Elsevier
Traumatic brain injury (TBI) is associated with a host of psychiatric and neurobehavioral
problems. As mortality rates have declined for severe TBI, attention has turned to the …

Examining later-in-life health risks associated with sport-related concussion and repetitive head impacts: a systematic review of case-control and cohort studies

GL Iverson, RJ Castellani, JD Cassidy… - British journal of sports …, 2023 - bjsm.bmj.com
Objective Concern exists about possible problems with later-in-life brain health, such as
cognitive impairment, mental health problems and neurological diseases, in former athletes …

A systematic review of potential long-term effects of sport-related concussion

G Manley, AJ Gardner, KJ Schneider… - British journal of sports …, 2017 - bjsm.bmj.com
Objective Systematic review of possible long-term effects of sports-related concussion in
retired athletes. Data sources Ten electronic databases. Study selection Original research; …

Tau and tauopathies

T Arendt, JT Stieler, M Holzer - Brain research bulletin, 2016 - Elsevier
Most neurodegenerative diseases are characterized by intracellular aggregates of insoluble
proteins. As for the majority of these disorders, aetiology and pathogenesis are only poorly …

Microglial activation in traumatic brain injury

CK Donat, G Scott, SM Gentleman… - Frontiers in aging …, 2017 - frontiersin.org
Microglia have a variety of functions in the brain, including synaptic pruning, CNS repair and
mediating the immune response against peripheral infection. Microglia rapidly become …

Impairment of glymphatic pathway function promotes tau pathology after traumatic brain injury

JJ Iliff, MJ Chen, BA Plog, DM Zeppenfeld… - Journal of …, 2014 - Soc Neuroscience
Traumatic brain injury (TBI) is an established risk factor for the early development of
dementia, including Alzheimer's disease, and the post-traumatic brain frequently exhibits …

Epidemiology of mild traumatic brain injury and neurodegenerative disease

RC Gardner, K Yaffe - Molecular and Cellular Neuroscience, 2015 - Elsevier
Every year an estimated 42 million people worldwide suffer a mild traumatic brain injury
(MTBI) or concussion. More severe traumatic brain injury (TBI) is a well-established risk …

Role of subconcussion in repetitive mild traumatic brain injury: a review

JE Bailes, AL Petraglia, BI Omalu, E Nauman… - Journal of …, 2013 - thejns.org
Research now suggests that head impacts commonly occur during contact sports in which
visible signs or symptoms of neurological dysfunction may not develop despite those …