Aldehyde dehydrogenase (ALDH) is a superfamily of enzymes that detoxify a variety of
endogenous and exogenous aldehydes and are required for the biosynthesis of retinoic …

Abstract Aldehyde dehydrogenase 2 (ALDH2) is a mitochondrial enzyme involved in the
detoxification of alcohol-derived acetaldehyde and endogenous aldehydes. The inactivating …

Critical limb ischemia (CLI), the most severe form of peripheral artery disease, is
characterized by pain at rest and non-healing ulcers in the lower extremities. For patients …

The therapeutic potential of mesenchymal stromal cells (MSCs) in the treatment of liver
fibrosis is predominantly based on their immunosuppressive properties, and their ability to …

A new source of mesenchymal stem cells has recently been discovered, the so-called dental
pulp derived stem cells (DPSCs) which therefore could represent potentially tools for …

Therapeutic angiogenesis with mesenchymal stem cells (MSCs) is promising for the clinical
treatment of peripheral artery disease (PAD). However, the heterogeneous proangiogenic …

Introduction Critical limb ischemia (CLI) is the most advanced form of peripheral arterial
disease (PAD) characterized by ischemic rest pain and non-healing ulcers. Currently, the …

Background Although a preponderance of pre-clinical data demonstrates the
immunosuppressive potential of mesenchymal stromal cells (MSCs), significant …

Mesenchymal stromal/stem cells (MSCs) have been developed as a promising source for
cell-based therapies of ischemic disease. However, there are some hurdles in their clinical …

Potency analysis of mesenchymal stromal cells (MSCs) is required for their use in advanced
clinical trials. Assay matrix strategy evaluating more than a single property of MSCs is an …