Recent advances in 4 (3 H)-quinazolinone syntheses

L He, H Li, J Chen, XF Wu - RSC advances, 2014 - pubs.rsc.org
The 4 (3H)-quinazolinone is a frequently encountered heterocycle with broad applications
including antimalarial, antitumor, anticonvulsant, fungicidal, antimicrobial, and anti …

Copper-mediated C–H (sp 2)/C–H (sp 3) coupling of benzoic acid derivatives with ethyl cyanoacetate: an expedient route to an isoquinolinone scaffold

W Zhu, D Zhang, N Yang, H Liu - Chemical Communications, 2014 - pubs.rsc.org
A facile, copper-mediated, direct C–H (sp2)/C–H (sp3) bond coupling of benzoic acid
derivatives with ethyl cyanoacetate by the deployment of an 8-aminoquinoline moiety as a …

Imidazolium chloride as an additive for synthesis of 4 (3H)-quinazolinones using anthranilamides and DMF derivatives

X Wang, S Shang, Q Tian, Y Wang, H Wu, Z Li, S Zhou… - Tetrahedron, 2020 - Elsevier
Imidazolium chloride as an environmentally benign additive efficiently facilitates construction
of 4 (3H)-quinazolinones using anthranilamides and DMF derivatives. A series of 4 (3H) …

Unexpected Insertion of Nitrogen into a C–C Bond: Access to 2, 3-Disubstituted Quinazolinone Scaffolds

HL Liu, XT Li, HZ Tian, XW Sun - Organic Letters, 2021 - ACS Publications
A novel, practical, highly efficient, and transition metal free nitrogen insertion reaction for the
synthesis of 2, 3-disubstituted quinazolinone derivatives was developed. Diverse …

Copper-catalyzed synthesis of benzocarbazoles via α-C-arylation of ketones

R Xie, Y Ling, H Fu - Chemical Communications, 2012 - pubs.rsc.org
A simple and efficient copper-catalyzed method for the synthesis of 11H-benzo [a]
carbazoles has been developed. The protocol uses readily available substituted 2-(2 …

Synthesis, antitumor activity, 3D-QSAR and molecular docking studies of new iodinated 4-(3 H)-quinazolinones 3 N-substituted

M Pérez-Fehrmann, V Kesternich, A Puelles… - RSC …, 2022 - pubs.rsc.org
A novel series of 6-iodo-2-methylquinazolin-4-(3H)-one derivatives, 3a–n, were synthesized
and evaluated for their in vitro cytotoxic activity. Compounds 3a, 3b, 3d, 3e, and 3h showed …

Facile assembly of two 6-membered fused N-heterocyclic rings: a rapid access to novel small molecules via Cu-mediated reaction

R Adepu, R Sunke, CLT Meda, D Rambabu… - Chemical …, 2013 - pubs.rsc.org
Facile assembly of two 6-membered fused N -heterocyclic rings: a rapid access to novel small
molecules via Cu-mediated reaction - Chemical Communications (RSC Publishing) …

Synthesis of benzopyridoindolone derivatives via a one-pot copper catalyzed tandem reaction of 2-iodobenzamide derivatives and 2-iodobenzylcyanides

V Kavala, Z Yang, A Konala, CY Huang… - The Journal of …, 2017 - ACS Publications
An efficient approach for the synthesis of benzo-fused pyridoindolone derivatives via a one-
pot copper catalyzed tandem reaction of 2-iodobenzamides with 2-iodobenzylcyanides has …

Synthesis of Fused Isoquinolinone and Iminoisoindolinone Derivatives via a Copper‐Catalyzed Regioselective Switching Process

V Kavala, CC Wang, YH Wang, CW Kuo… - Advanced Synthesis …, 2014 - Wiley Online Library
Copper‐catalyzed base switching procedures for the synthesis of various fused
isoquinolinone derivatives and iminoisoindolinone derivatives from the same starting …

Copper-Catalyzed Tandem Reactions for Synthesis of Pyrazolo[5,1-a]isoquinolines with Heterocyclic Ketene Aminals as Ligands

LR Wen, XJ Jin, XD Niu, M Li - The Journal of Organic Chemistry, 2015 - ACS Publications
A CuI-catalyzed tandem reaction of 5-(2-bromoaryl)-N-aryl-1 H-pyrazol-3-amines with active
acetonitrile derivatives to prepare pyrazolo [5, 1-a] isoquinolines in good to excellent yields …