SUMMARY β-Lactam antibiotics have been widely used as therapeutic agents for the past
70 years, resulting in emergence of an abundance of β-lactam-inactivating β-lactamases …

Klebsiella pneumoniae is a Gram-negative pathogen that has a large accessory genome of
plasmids and chromosomal gene loci. This accessory genome divides K. pneumoniae …

目的了解国内主要地区临床分离菌对常用抗菌药物的敏感性和耐药性. 方法对国内主要地区(13
所综合性医院, 2 所儿童医院) 临床分离菌采用纸片扩散法或自动化仪器法按统一方案进行细菌 …

Carbapenem resistance is a major and an on-going public health problem globally. It occurs
mainly among Gram-negative pathogens such as Klebsiella pneumoniae, Pseudomonas …

There is an enormous global public health burden due to antimicrobial-resistant (AMR)
Klebsiella pneumoniae high-risk clones. K. pneumoniae ST307 and ST147 are recent …

The emergence of carbapenem-resistant Gram-negative pathogens poses a serious threat
to public health worldwide. In particular, the increasing prevalence of carbapenem-resistant …

The global emergence of carbapenemase-producing bacteria capable of hydrolyzing the
once effective carbapenem antibiotics is considered a contemporary public health concern …

Escherichia coli sequence type 131 (ST131) and Klebsiella pneumoniae ST258 emerged in
the 2000s as important human pathogens, have spread extensively throughout the world …

The OXA β-lactamases were among the earliest β-lactamases detected; however, these
molecular class D β-lactamases were originally relatively rare and always plasmid …

The spread of carbapenemase producers in Enterobacteriaceae has now been identified
worldwide. Three main carbapenemases have been reported; they belong to three classes …