Neutrophil intrinsic and extrinsic regulation of NETosis in health and disease

V Poli, I Zanoni - Trends in microbiology, 2023 - cell.com
Neutrophil extracellular traps (NETs) evolved to protect the host against microbial infections
and are formed by a web-like structure of DNA that is decorated with antimicrobial effectors …

Neutrophil extracellular traps in immunity and disease

V Papayannopoulos - Nature Reviews Immunology, 2018 - nature.com
Neutrophils are innate immune phagocytes that have a central role in immune defence. Our
understanding of the role of neutrophils in pathogen clearance, immune regulation and …

Diverse stimuli engage different neutrophil extracellular trap pathways

EF Kenny, A Herzig, R Krüger, A Muth, S Mondal… - Elife, 2017 - elifesciences.org
Neutrophils release neutrophil extracellular traps (NETs) which ensnare pathogens and
have pathogenic functions in diverse diseases. We examined the NETosis pathways …

Neutrophil activated by the famous and potent PMA (Phorbol myristate acetate)

HL Damascena, WAA Silveira, MS Castro, W Fontes - Cells, 2022 - mdpi.com
This review will briefly outline the major signaling pathways in PMA-activated neutrophils.
PMA is widely used to understand neutrophil pathways and formation of NETs. PMA …

Neutrophils discriminate between lipopolysaccharides of different bacterial sources and selectively release neutrophil extracellular traps

E Pieterse, N Rother, C Yanginlar… - Frontiers in …, 2016 - frontiersin.org
The release of neutrophil extracellular traps (NETs), either during “suicidal” or “vital”
NETosis, represents an important strategy of neutrophils to combat Gram-negative bacteria …

Respiratory Syncytial Virus induces the classical ROS-dependent NETosis through PAD-4 and necroptosis pathways activation

SP Muraro, GF De Souza, SW Gallo, BK Da Silva… - Scientific reports, 2018 - nature.com
Respiratory syncytial virus (RSV) is a major cause of diseases of the respiratory tract in
young children and babies, being mainly associated with bronchiolitis. RSV infection occurs …

Neutrophil extracellular traps: signaling properties and disease relevance

T Li, Z Zhang, X Li, G Dong, M Zhang… - Mediators of …, 2020 - Wiley Online Library
Neutrophil extracellular traps (NETs) are characterized as extracellular DNA fibers
comprised of histone and cytoplasmic granule proteins. NETs were first described as a form …

Re-Du-Ning injection ameliorates LPS-induced lung injury through inhibiting neutrophil extracellular traps formation

C Yang, C Song, Y Liu, J Qu, H Li, W Xiao, L Kong… - Phytomedicine, 2021 - Elsevier
Background Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are life-
threatening diseases and could occur in severe COVID-19 patients. Re-Du-Ning injection …

Fungal sensing enhances neutrophil metabolic fitness by regulating antifungal Glut1 activity

DD Li, CV Jawale, C Zhou, L Lin, GJ Trevejo-Nunez… - Cell host & …, 2022 - cell.com
Combating fungal pathogens poses metabolic challenges for neutrophils, key innate cells in
anti-Candida albicans immunity, yet how host-pathogen interactions cause remodeling of …

How neutrophil metabolism affects bacterial killing

JE Toller-Kawahisa, LAJ O'Neill - Open Biology, 2022 - royalsocietypublishing.org
Neutrophils are front line cells in immunity that quickly recognize and eliminate pathogens,
relying mainly on glycolysis to exert their killing functions. Even though investigations into …