The retinoblastoma (RB) protein family members (pRB, p107 and p130) are key regulators
of cell cycle progression, but also play crucial roles in apoptosis, and stem cell self-renewal …

So far there has been no comprehensive review using systematic literature search strategies
to show the application of single-cell RNA sequencing (scRNA-seq) in the human testis of …

Meiosis is a key step during germ cell differentiation, accompanied by the activation of
thousands of genes through germline-specific chromatin reorganization. The chromatin …

Spermatogenic regeneration is key for male fertility and relies on activities of an
undifferentiated spermatogonial population. Here, a high-throughput approach with primary …

Spermatogenesis is sustained by homeostatic balance between the self-renewal and
differentiation of spermatogonial stem cells, which is dependent on the strict regulation of …

Chromodomain helicase DNA-binding domain 2 (CHD2) is a chromatin remodeling factor
involved in many developmental processes. However, its role in male germ cell …

Spermatogonial stem cells (SSCs) are essential for continuous spermatogenesis and male
fertility. The underlying mechanisms of alternative splicing (AS) in mouse SSCs are still …

Spermatogonial stem cell (SSC) function is essential for male fertility, and these cells hold
potential therapeutic value spanning from human infertility treatments to wildlife …

The chromatin remodeler Chromodomain-helicase-DNA-binding protein 4 (CHD4) is crucial
for the development of multiple organ systems. Functional mutations of CHD4 have recently …

Testis development and sustained germ cell production in adults rely on the establishment
and maintenance of spermatogonia stem cells and their proper differentiation into …