Radiotherapy is one of the most common treatments for oral cancer. However, in the clinic,
recurrence and metastasis of oral cancer occur after radiotherapy, and the underlying …

Re-irradiation is becoming an established treatment option for recurrent or second primary
head and neck cancer (HNC). However, acute and long-term RT-related toxicities could …

Radiotherapy is an important therapeutic strategy for cancer treatment through direct
damage to cancer cells and augmentation of antitumor immune responses. However, the …

Tumors are composed of subpopulations of cancer cells with functionally distinct features.
Intratumoral heterogeneity limits the therapeutic effectiveness of cancer drugs. To address …

Concurrent chemotherapy and radiotherapy (CRT) has become standard treatment for many
patients with advanced head and neck squamous cell carcinoma (HNSCC). This has led to …

The role of p53 in genotoxic therapy-induced metabolic shift in cancers is not yet known. In
this study, we investigated the role of p53 in the glycolytic shift in head and neck squamous …

PURPOSE: This randomized phase III trial investigated the potential benefit of concurrent re-
irradiation, fluorouracil and hydroxyurea versus methotrexate for patients treated with …

Background: In order to improve therapy for HNSCC patients, novel methods to predict and
combat local and/or distant tumour relapses are urgently needed. This study has been …

Management of patients with recurrent head and neck cancer remains a challenge for the
surgeon as well as the treating radiation oncologist. Even in the era of modern radiotherapy …

Background and purpose A multicenter prospective randomized controlled trial was
performed to investigate whether dose reduction to the elective nodal volume (PTVelect) in …