Autophagy, a multistep lysosomal degradation pathway that supports nutrient recycling and
metabolic adaptation, has been implicated as a process that regulates cancer. Although …

Autophagy is a conserved, self‐degradation system that is critical for maintaining cellular
homeostasis during stress conditions. Dysregulated autophagy has implications in health …

Autophagy is an essential cellular mechanism which plays “housekeeping” role in normal
physiological processes including removing of long lived, aggregated and misfolded …

Drug resistance is a major challenge in cancer treatment. Emerging evidence indicates that
deregulation of YAP/TAZ signaling may be a major mechanism of intrinsic and acquired …

Eukaryotes use autophagy as a mechanism for maintaining cellular homeostasis by
degrading and recycling organelles and proteins. This process assists in the proliferation …

In 2008, we published the first set of guidelines for standardizing research in autophagy.
Since then, this topic has received increasing attention, and many scientists have entered …

Yes-associated protein (YAP), the central mediator of Hippo pathway, not only regulates a
diversity of cellular processes during development but also plays a pivotal role in …

The Hippo pathway coordinates extracellular signals onto the control of tissue homeostasis
and organ size. Hippo signaling primarily regulates the ability of Yap1 to bind and co …

Abstract Purpose: Glioblastomas (GBMs), neoplasms derived from glia and neuroglial
progenitor cells, are the most common and lethal malignant primary brain tumors diagnosed …

Dysregulation of the Hippo signaling pathway and the consequent YAP1 activation is a
frequent event in human malignancies, yet the underlying molecular mechanisms are still …