Diabetes mellitus currently affects more than 170 million individuals worldwide and is
expected to afflict another 200 million individuals in the next 30 years. Complications of …

In addition to a number of deleterious effects on cellular integrity and functions, diabetic
metabolic milieu has been implicated in a rapidly growing number of alterations in signal …

We tested the hypothesis that AMP-activated protein kinase (AMPK), an energy sensor,
regulates diabetes-induced renal hypertrophy. In kidney glomerular epithelial cells, high …

Insulin resistance is a central component of the metabolic dysregulation observed in obesity,
which puts one at risk for the development of type 2 diabetes and complications related to …

The mammalian target of rapamycin (mTOR) inhibitors are drugs, primarily used as
immunosuppressors that are now frequently used as antineoplastic therapies in various …

Ionizing radiation (IR) is a physiologically important stress to which cells respond by the
activation of multiple signaling pathways. Using a panel of immortalized and transformed …

The phorbol ester, 12-O-tetradecanoylphorbol 13-acetate (TPA), a potent stimulator of Erk,
leads to the phosphorylation of 4E-BP1 and its dissociation from eIF4E. In contrast to …

Neurodegenerative disorders affect a significant portion of the world's population leading to
either disability or death for almost 30 million individuals worldwide. One novel therapeutic …

Abstract Insulin‐like growth factor‐1 (IGF‐1) interacts with the Type I receptor to activate two
main signaling pathways, the mitogen‐activated protein kinase kinase (MEK)‐extracellular …

Neurodegenerative disorders lead to disability and death in a significant proportion of the
world's population. However, many disorders of the nervous system remain with limited …