We propose a cell detection algorithm using non-negative matrix factorization (NMF) on Ca
2+ imaging data. To apply NMF to Ca 2+ imaging data, we use the bleaching line of the …

Large-scale recording from a population of neurons is a promising strategy for approaching
the study of complex brain functions. Taking advantage of the fact that action potentials …

The ability of synchronous population activity in layered networks to transmit a rate code is a
focus of recent debate. We investigate these issues using a patterned unidimensional …

Staining brain slices with acetoxymethyl ester (AM) Ca2+ dyes is a straightforward
procedure to load multiple cells, and Fluo‐4 is a commonly used high‐affinity indicator due …

The neurotrophic factors brain‐derived neurotrophic factor (BDNF) and neurotrophin‐3 (NT‐
3) have been shown to promote excitatory and inhibitory synapse development. However, a …

The calcium ion (Ca2+) is an important messenger for signal transduction, and the
intracellular Ca2+ concentration ([Ca2+] i) changes in response to an excitation of the cell …

Neurons might interact via electric fields and this notion has been referred to as ephaptic
interaction. It has been shown that various types of ion channels are distributed along the …

Photometric patch electrode (PME) measures optical signal of neurons simultaneously with
electrical activity in deep brain tissues. As a light guide, PME transmits laser light to the tip of …

This is perhaps the most beautiful time in human history; it is really pregnant with all kinds of
creative possibilities made possible by science and technology. Jonas Salk's quotation …

The human central nervous system, one of the most complex organ systems anatomically
and physiologically in the human body, is the body control center which manages and …