Many cellular processes require large-scale rearrangements of chromatin structure.
Structural maintenance of chromosomes (SMC) protein complexes are molecular machines …

SMC (structural maintenance of chromosomes) protein complexes are an evolutionarily
conserved family of motor proteins that hold sister chromatids together and fold genomes …

In eukaryotes, genomic DNA is extruded into loops by cohesin. By restraining this process,
the DNA-binding protein CCCTC-binding factor (CTCF) generates topologically associating …

SMC protein complexes are molecular machines that provide structure to chromosomes.
These complexes bridge DNA elements and by doing so build DNA loops in cis and hold …

Eukaryotic genomes are compacted into loops and topologically associating domains
(TADs),–, which contribute to transcription, recombination and genomic stability,. Cohesin …

The topological state of chromosomes determines their mechanical properties, dynamics,
and function. Recent work indicated that interphase chromosomes are largely free of …

Cohesin folds the genome in dynamic chromatin loops and holds the sister chromatids
together. NIPBL Scc2 is currently considered the cohesin loader, a role that may need …

Cohesin connects CTCF-binding sites and other genomic loci in cis to form chromatin loops
and replicated DNA molecules in trans to mediate sister chromatid cohesion. Whether …

Cohesin organizes the genome through the formation of chromatin loops. NIPBL activates
cohesin's ATPase and is essential for loop extrusion, but its requirement for cohesin loading …

The ring model proposes that sister chromatid cohesion is mediated by co-entrapment of
sister DNAs inside a single tripartite cohesin ring. The model explains how Scc1 cleavage …