The promise of circulating tumor DNA in head and neck cancer
SS Aulakh, DA Silverman, K Young, SK Dennis… - Cancers, 2022 - mdpi.com
Simple Summary Head and neck cancer remains a challenging and deadly disease as it is
often identified in more advanced stages due to limitations in screening and surveillance …
often identified in more advanced stages due to limitations in screening and surveillance …
Emerging precision diagnostics in advanced cutaneous squamous cell carcinoma
G Geidel, I Heidrich, J Kött, SW Schneider… - NPJ Precision …, 2022 - nature.com
Advanced cutaneous squamous cell carcinoma (cSCC) encompasses unresectable and
metastatic disease. Although immune checkpoint inhibition has been approved for this entity …
metastatic disease. Although immune checkpoint inhibition has been approved for this entity …
Cancer progression gene expression profiling identifies the urokinase plasminogen activator receptor as a biomarker of metastasis in cutaneous squamous cell …
Cutaneous squamous cell carcinoma (cSCC) of the head and neck region is the second
most prevalent skin cancer, with metastases to regional lymph nodes occurring in 2%–5% of …
most prevalent skin cancer, with metastases to regional lymph nodes occurring in 2%–5% of …
[HTML][HTML] Genomic evidence suggests that cutaneous neuroendocrine carcinomas can arise from squamous dysplastic precursors
PW Harms, ME Verhaegen, K Hu, SM Hrycaj… - Modern Pathology, 2022 - Elsevier
Merkel cell carcinoma (MCC) is an aggressive cutaneous neuroendocrine carcinoma
without a known dysplastic precursor. In some cases, MCC is associated with SCCIS in the …
without a known dysplastic precursor. In some cases, MCC is associated with SCCIS in the …
Invasive squamous cell carcinomas and precursor lesions on UV-exposed epithelia demonstrate concordant genomic complexity in driver genes
Although squamous cell carcinomas (SCC) are the most frequent human solid tumor at
many anatomic sites, the driving molecular alterations underlying their progression from …
many anatomic sites, the driving molecular alterations underlying their progression from …
[HTML][HTML] Mutational patterns in metastatic cutaneous squamous cell carcinoma
Cutaneous squamous cell carcinoma from the head and neck typically metastasize to the
lymph nodes of the neck and parotid glands. When a primary is not identified, they are …
lymph nodes of the neck and parotid glands. When a primary is not identified, they are …
Next-generation sequencing in dermatology
AD King, H Deirawan, PA Klein, B Dasgeb… - Frontiers in …, 2023 - frontiersin.org
Over the past decade, Next-Generation Sequencing (NGS) has advanced our
understanding, diagnosis, and management of several areas within dermatology. NGS has …
understanding, diagnosis, and management of several areas within dermatology. NGS has …
Molecular alterations in cutaneous squamous cell carcinoma in immunocompetent and immunosuppressed hosts—A systematic review
DA Tsang, SYC Tam, CC Oh - Cancers, 2023 - mdpi.com
Simple Summary Cutaneous squamous cell carcinoma (cSCC) is the second most common
form of skin cancer worldwide. Due to its high mutational burden, cSCC remains poorly …
form of skin cancer worldwide. Due to its high mutational burden, cSCC remains poorly …
Whole genome analysis reveals the genomic complexity in metastatic cutaneous squamous cell carcinoma
Metastatic cutaneous squamous cell carcinoma (CSCC) is a highly morbid disease requiring
radical surgery and adjuvant therapy, which is associated with a poor prognosis. Yet …
radical surgery and adjuvant therapy, which is associated with a poor prognosis. Yet …
High-Dimensional and Spatial Analysis Reveals Immune Landscape–Dependent Progression in Cutaneous Squamous Cell Carcinoma
Purpose: The tumor immune microenvironment impacts the biological behavior of the tumor,
but its effect on clinical outcomes in head and neck cutaneous squamous cell carcinomas …
but its effect on clinical outcomes in head and neck cutaneous squamous cell carcinomas …