Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb) remains as a leading killer
among infectious diseases worldwide. The nature of the host immune response dictates …

Lung cancer is among the most common malignant tumors worldwide, and is characterized
by a low survival rate compared with other cancers. Toll-like receptors (TLRs) are highly …

Mycobacterium tuberculosis (Mtb) infection activates the NLRP3 inflammasome in
macrophages and dendritic cells. Much attention has been paid to the mechanisms for …

Being among the top 10 causes of adult deaths, tuberculosis (TB) disease is considered a
major global public health concern to address. The human tuberculosis pathogen …

Host cells undergo complex transcriptional reprogramming upon infection. Epigenetic
changes play a key role in the immune response to bacteria, among which DNA …

Epigenetic mechanisms are pivotal in regulating gene expression during cellular response
to extracellular stimuli. Bacterial infections have a profound effect on the host epigenome …

To prevent damage to the host or its commensal microbiota, epithelial tissues must match
the intensity of the immune response to the severity of a biological threat. Toll-like receptors …

We hypothesized that DNA methylation patterns may contribute to the development of active
pulmonary tuberculosis (TB). Illumina's DNA methylation 450 K assay was used to identify …

Abstract Study Objectives We hypothesized that DNA methylation patterns may contribute to
disease severity or the development of hypertension and excessive daytime sleepiness …

Epigenetic mechanisms have rapidly and controversially emerged as silent modulators of
host defenses that can lead to a more prominent immune response and shape the course of …