TAR DNA binding protein 43 (TDP-43) is a versatile RNA/DNA binding protein involved in
RNA-related metabolism. Hyper-phosphorylated and ubiquitinated TDP-43 deposits act as …

Neurodegenerative diseases pose a substantial socioeconomic burden on society.
Unfortunately, the aging world population and lack of effective cures foreshadow a negative …

The multiple roles played by RNA binding proteins in neurodegeneration have become
apparent following the discovery of TAR DNA binding protein 43 kDa (TDP‐43) and fused in …

Eukaryotic cells contain distinct organelles, but not all of these compartments are enclosed
by membranes. Some intrinsically disordered proteins mediate membraneless organelle …

A dominant histopathological feature in neuromuscular diseases, including amyotrophic
lateral sclerosis and inclusion body myopathy, is cytoplasmic aggregation of the RNA …

Insoluble protein aggregates are the hallmarks of many neurodegenerative diseases. For
example, aggregates of TDP-43 occur in nearly all cases of amyotrophic lateral sclerosis …

Transactive response DNA binding protein (TDP-43) is a key player in neurodegenerative
diseases. In this review, we have gathered and presented structural information on the …

TDP-43 accumulates in nerve cells of nearly all cases of amyotrophic lateral sclerosis (ALS;
the commonest form of motor neuron disease) and in the majority of Tau-negative …

Aggregates of the RNA-binding protein TDP-43 (TAR DNA-binding protein) are a hallmark of
the overlapping neurodegenerative disorders amyotrophic lateral sclerosis (ALS) and …

Neurodegeneration is a leading cause of death in the developed world and a natural, albeit
unfortunate, consequence of longer-lived populations. Despite great demand for therapeutic …