Protein kinase C: perfectly balanced
AC Newton - Critical reviews in biochemistry and molecular …, 2018 - Taylor & Francis
Protein kinase C (PKC) isozymes belong to a family of Ser/Thr kinases whose activity is
governed by reversible release of an autoinhibitory pseudosubstrate. For conventional and …
governed by reversible release of an autoinhibitory pseudosubstrate. For conventional and …
Dynamics-driven allostery in protein kinases
AP Kornev, SS Taylor - Trends in biochemical sciences, 2015 - cell.com
Protein kinases have very dynamic structures and their functionality strongly depends on
their dynamic state. Active kinases reveal a dynamic pattern with residues clustering into …
their dynamic state. Active kinases reveal a dynamic pattern with residues clustering into …
mTORC2 controls the activity of PKC and Akt by phosphorylating a conserved TOR interaction motif
TR Baffi, G Lordén, JM Wozniak, A Feichtner… - Science …, 2021 - science.org
The complex mTORC2 is accepted to be the kinase that controls the phosphorylation of the
hydrophobic motif, a key regulatory switch for AGC kinases, although whether mTOR directly …
hydrophobic motif, a key regulatory switch for AGC kinases, although whether mTOR directly …
Ca2+ releases E‐Syt1 autoinhibition to couple ER‐plasma membrane tethering with lipid transport
The extended synaptotagmins (E‐Syts) are endoplasmic reticulum (ER) proteins that bind
the plasma membrane (PM) via C2 domains and transport lipids between them via SMP …
the plasma membrane (PM) via C2 domains and transport lipids between them via SMP …
AGC kinases, mechanisms of regulation and innovative drug development
The group of AGC kinases consists of 63 evolutionarily related serine/threonine protein
kinases comprising PDK1, PKB/Akt, SGK, PKC, PRK/PKN, MSK, RSK, S6K, PKA, PKG …
kinases comprising PDK1, PKB/Akt, SGK, PKC, PRK/PKN, MSK, RSK, S6K, PKA, PKG …
Equivocal, explicit and emergent actions of PKC isoforms in cancer
PJ Parker, SJ Brown, V Calleja, P Chakravarty… - Nature Reviews …, 2021 - nature.com
The maturing mutational landscape of cancer genomes, the development and application of
clinical interventions and evolving insights into tumour-associated functions reveal …
clinical interventions and evolving insights into tumour-associated functions reveal …
Reversing the paradigm: protein kinase C as a tumor suppressor
AC Newton, J Brognard - Trends in pharmacological sciences, 2017 - cell.com
The discovery in the 1980s that protein kinase C (PKC) is a receptor for the tumor-promoting
phorbol esters fueled the dogma that PKC is an oncoprotein. Yet 30+ years of clinical trials …
phorbol esters fueled the dogma that PKC is an oncoprotein. Yet 30+ years of clinical trials …
Protein kinase C in fungi—more than just cell wall integrity
JJ Heinisch, R Rodicio - FEMS Microbiology Reviews, 2018 - academic.oup.com
Human protein kinase C (PKC) isoforms have been implicated in diseases such as
Alzheimer's, diabetes and cancers. In contrast to mammals, which have at least nine genes …
Alzheimer's, diabetes and cancers. In contrast to mammals, which have at least nine genes …
Conventional protein kinase C in the brain: 40 years later
JA Callender, AC Newton - Neuronal signaling, 2017 - portlandpress.com
Protein kinase C (PKC) is a family of enzymes whose members transduce a large variety of
cellular signals instigated by the receptor-mediated hydrolysis of membrane phospholipids …
cellular signals instigated by the receptor-mediated hydrolysis of membrane phospholipids …
Protein kinase C as a tumor suppressor
AC Newton - Seminars in cancer biology, 2018 - Elsevier
Protein kinase C (PKC) has historically been considered an oncoprotein. This stems in large
part from the discovery in the early 1980s that PKC is directly activated by tumor-promoting …
part from the discovery in the early 1980s that PKC is directly activated by tumor-promoting …